SOX10 and POU3F2

Number of citations of the paper that reports this interaction (PubMedID 11029584)
0

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid)

		SOX10	POU3F2
Description		SRY-box transcription factor 10	POU class 3 homeobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Neuroblast Proliferation Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Gene Expression Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Cell Differentiation Melanocyte Differentiation Positive Regulation Of Myelination Developmental Process Lacrimal Gland Development Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Stem Cell Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Cellular Response To Xenobiotic Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Epidermis Development Negative Regulation Of Gene Expression Schwann Cell Development Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Forebrain Astrocyte Development Central Nervous System Neuron Differentiation Hypothalamus Cell Differentiation Neurohypophysis Development Myelination In Peripheral Nervous System Cell Differentiation Neuron Differentiation Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development Regulation Of Axonogenesis Neuroendocrine Cell Differentiation
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of CDH19 Expression and Function Regulation of MITF-M-dependent genes involved in pigmentation Transcriptional and post-translational regulation of MITF-M expression and activity	EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of MITF-M-dependent genes involved in apoptosis Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases		Waardenburg syndrome (WS) 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		Mean spheric corpuscular volume ( 32888494)	Bipolar disorder ( 34002096 24618891 33263727 27329760) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Caffeine consumption from coffee or tea ( 33287642) Chronotype ( 30696823) Educational attainment ( 25201988) Erectile dysfunction ( 30583798) General risk tolerance (MTAG) ( 30643258) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) QT interval (drug interaction) ( 23459443) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		44 interacting genes: ALX4 C10orf55 CDK6 CEBPA CRX CTNNB1 DAZAP2 DLX5 EGR2 ERG EXOC5 GSK3B HHEX HIVEP1 HNF1B HOXA3 HOXC4 HSF4 JUN MAGED1 MAPK1 MEOX1 NFIC NFIX NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 POU6F2 PRRX1 PRRX2 RCAN1 RSPH1 SP1 SUMO1 SUMO2 SUMO3 TCF12 TIAM1 UBE2I UTF1	15 interacting genes: COASY EP300 GTF2B KCNQ5 LGALS13 NFYA NFYB NFYC PAX3 POU3F4 PQBP1 SMIM8 SOX10 SOX11 TBP
Entrez ID		6663	5454
HPRD ID		03752	02734
Ensembl ID		ENSG00000100146	ENSG00000184486
Uniprot IDs		P56693	P20265
PDB IDs			7XRC
Enriched GO Terms of Interacting Partners?		HMG Box Domain Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding System Development Negative Regulation Of RNA Metabolic Process Animal Organ Development Developmental Process Animal Organ Morphogenesis Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Embryonic Organ Morphogenesis Nucleoplasm Ubiquitin Protein Ligase Binding Cell Fate Specification Transcription Coregulator Binding Protein Sumoylation	Protein-DNA Complex CCAAT-binding Factor Complex Chromatin Transcription Cis-regulatory Region Binding DNA Binding DNA-binding Transcription Factor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-templated Transcription Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Acetyltransferase Activity Regulation Of Transcription Regulatory Region DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Protein-lysine-acetyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Oligodendrocyte Development Histone Acetyltransferase Activity Transcription Factor TFIID Complex Positive Regulation Of Macromolecule Metabolic Process Protein Acetylation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity RNA Metabolic Process Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Transcriptional Start Site Selection At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly
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