POU3F2 and COASY

		POU3F2	COASY
Description		POU class 3 homeobox 2	Coenzyme A synthase
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Catalytic Activity Dephospho-CoA Kinase Activity Pantetheine-phosphate Adenylyltransferase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Nucleotidyltransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Epidermis Development Negative Regulation Of Gene Expression Schwann Cell Development Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Forebrain Astrocyte Development Central Nervous System Neuron Differentiation Hypothalamus Cell Differentiation Neurohypophysis Development Myelination In Peripheral Nervous System Cell Differentiation Neuron Differentiation Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development Regulation Of Axonogenesis Neuroendocrine Cell Differentiation	Coenzyme A Biosynthetic Process
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of MITF-M-dependent genes involved in apoptosis Transcriptional and post-translational regulation of MITF-M expression and activity	Coenzyme A biosynthesis
Drugs
Diseases
GWAS		Bipolar disorder ( 34002096 24618891 33263727 27329760) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Caffeine consumption from coffee or tea ( 33287642) Chronotype ( 30696823) Educational attainment ( 25201988) Erectile dysfunction ( 30583798) General risk tolerance (MTAG) ( 30643258) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) QT interval (drug interaction) ( 23459443) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552)
Interacting Genes		15 interacting genes: COASY EP300 GTF2B KCNQ5 LGALS13 NFYA NFYB NFYC PAX3 POU3F4 PQBP1 SMIM8 SOX10 SOX11 TBP	14 interacting genes: APP BTK CFTR CNTROB IFT20 KIAA1958 KRT20 LYN PJA1 POU3F2 RPS6KB1 RPS6KB2 SRC SYK
Entrez ID		5454	80347
HPRD ID		02734	13080
Ensembl ID		ENSG00000184486	ENSG00000068120
Uniprot IDs		P20265	Q13057
PDB IDs		7XRC
Enriched GO Terms of Interacting Partners?		Protein-DNA Complex CCAAT-binding Factor Complex Chromatin Transcription Cis-regulatory Region Binding DNA Binding DNA-binding Transcription Factor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-templated Transcription Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Acetyltransferase Activity Regulation Of Transcription Regulatory Region DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Protein-lysine-acetyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Oligodendrocyte Development Histone Acetyltransferase Activity Transcription Factor TFIID Complex Positive Regulation Of Macromolecule Metabolic Process Protein Acetylation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity RNA Metabolic Process Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Transcriptional Start Site Selection At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly	Signaling Receptor Activator Activity Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Fc Receptor Signaling Pathway TORC1 Signaling Phospholipase Binding Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin TOR Signaling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Protein Tyrosine Kinase Activity Cellular Response To Molecule Of Fungal Origin Integrin Binding Kinase Activity Histamine Secretion By Mast Cell Protein Phosphorylation Response To Molecule Of Fungal Origin Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Pattern Recognition Receptor Signaling Pathway Cellular Developmental Process Phosphorylation B Cell Receptor Signaling Pathway Positive Regulation Of Cell Activation Innate Immune Response-activating Signaling Pathway Histamine Secretion Regulation Of Inflammatory Response Regulation Of Innate Immune Response Glial Cell Development Activation Of Innate Immune Response Positive Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Membrane Raft Response To Lipid Positive Regulation Of Defense Response Histamine Transport Cellular Response To Lipid Positive Regulation Of Protein Metabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Scaffold Protein Binding Positive Regulation Of Developmental Process Phospholipase Activator Activity
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