POU3F2 and SMIM8

		POU3F2	SMIM8
Description		POU class 3 homeobox 2	small integral membrane protein 8
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Mitochondrion Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Epidermis Development Negative Regulation Of Gene Expression Schwann Cell Development Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Forebrain Astrocyte Development Central Nervous System Neuron Differentiation Hypothalamus Cell Differentiation Neurohypophysis Development Myelination In Peripheral Nervous System Cell Differentiation Neuron Differentiation Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development Regulation Of Axonogenesis Neuroendocrine Cell Differentiation
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of MITF-M-dependent genes involved in apoptosis Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Bipolar disorder ( 34002096 24618891 33263727 27329760) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Caffeine consumption from coffee or tea ( 33287642) Chronotype ( 30696823) Educational attainment ( 25201988) Erectile dysfunction ( 30583798) General risk tolerance (MTAG) ( 30643258) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) QT interval (drug interaction) ( 23459443) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		15 interacting genes: COASY EP300 GTF2B KCNQ5 LGALS13 NFYA NFYB NFYC PAX3 POU3F4 PQBP1 SMIM8 SOX10 SOX11 TBP	1 interacting genes: POU3F2
Entrez ID		5454	57150
HPRD ID		02734	12862
Ensembl ID		ENSG00000184486	ENSG00000111850
Uniprot IDs		P20265	Q96KF7 V9GYF9
PDB IDs		7XRC
Enriched GO Terms of Interacting Partners?		Protein-DNA Complex CCAAT-binding Factor Complex Chromatin Transcription Cis-regulatory Region Binding DNA Binding DNA-binding Transcription Factor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-templated Transcription Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Acetyltransferase Activity Regulation Of Transcription Regulatory Region DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Protein-lysine-acetyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Oligodendrocyte Development Histone Acetyltransferase Activity Transcription Factor TFIID Complex Positive Regulation Of Macromolecule Metabolic Process Protein Acetylation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity RNA Metabolic Process Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Transcriptional Start Site Selection At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly	Forebrain Astrocyte Development Neurohypophysis Development Hypothalamus Cell Differentiation Forebrain Ventricular Zone Progenitor Cell Division Neuroendocrine Cell Differentiation Astrocyte Development Schwann Cell Development Cerebral Cortex Radially Oriented Cell Migration Myelination In Peripheral Nervous System Cerebral Cortex Cell Migration Neuron Fate Specification Positive Regulation Of Multicellular Organism Growth Neuroepithelial Cell Differentiation Neuron Fate Commitment Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Multicellular Organism Growth Glial Cell Development Cell Fate Specification Myelination Axon Ensheathment Central Nervous System Neuron Differentiation Regulation Of Axonogenesis Epidermis Development Positive Regulation Of Developmental Growth Neuron Development Cell Fate Commitment Transcription Regulator Complex Brain Development Positive Regulation Of Growth
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