RTN4R and ZDHHC8

		RTN4R	ZDHHC8
Description		reticulon 4 receptor	zDHHC palmitoyltransferase 8
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Axon Dendrite Growth Cone Cell Projection Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome Side Of Membrane Glutamatergic Synapse	Golgi Membrane Mitochondrion Golgi Apparatus Cytosol Membrane Mitochondrial Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Heparin Binding Lipid Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Ganglioside GM1 Binding Ganglioside GT1b Binding	Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Axonogenesis Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration Regulation Of Synapse Assembly Regulation Of Postsynapse Assembly	Locomotory Behavior Positive Regulation Of Cholesterol Efflux Peptidyl-L-cysteine S-palmitoylation High-density Lipoprotein Particle Assembly Host-mediated Activation Of Viral Process Regulation Of Postsynapse Assembly Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Axonal growth inhibition (RHOA activation)	HDL assembly Maturation of spike protein
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Obesity-related traits ( 23251661)
Interacting Genes		13 interacting genes: HOXA1 KEAP1 LINGO1 MAG MGAT5B NEK1 NGFR OMG OTX1 PTK7 RTN4 RTN4IP1 ZDHHC8	5 interacting genes: MICAL3 MRPL40 PPIL2 RTL10 RTN4R
Entrez ID		65078	29801
HPRD ID		16123	12298
Ensembl ID		ENSG00000040608	ENSG00000099904
Uniprot IDs		Q9BZR6	Q9ULC8
PDB IDs		1OZN 1P8T
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Cochlea Morphogenesis Blood Vessel Development Neuron Projection Regeneration Regulation Of Neuron Projection Development Negative Regulation Of Axon Extension Artery Development Semicircular Canal Formation Developmental Process Negative Regulation Of Axonogenesis Nervous System Development Diencephalon Morphogenesis Regulation Of Postsynapse Assembly Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Coreceptor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Abducens Nerve Formation Optokinetic Behavior Mesaxon Regulation Of Cell Projection Organization Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Regulation Of Axon Extension Ganglioside GT1b Binding Death Receptor Activity Metencephalon Development Positive Regulation Of Protein Localization To Endoplasmic Reticulum	F-actin Monooxygenase Activity Neuregulin Receptor Activity Ganglioside GT1b Binding Ganglioside GM1 Binding
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