ZDHHC8 and RTN4R

		ZDHHC8	RTN4R
Description		zDHHC palmitoyltransferase 8	reticulon 4 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Mitochondrion Golgi Apparatus Cytosol Membrane Mitochondrial Membrane Postsynapse Glutamatergic Synapse	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Axon Dendrite Growth Cone Cell Projection Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome Side Of Membrane Glutamatergic Synapse
	Molecular Function	Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	Protein Binding Heparin Binding Lipid Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Ganglioside GM1 Binding Ganglioside GT1b Binding
	Biological Process	Locomotory Behavior Positive Regulation Of Cholesterol Efflux Peptidyl-L-cysteine S-palmitoylation High-density Lipoprotein Particle Assembly Host-mediated Activation Of Viral Process Regulation Of Postsynapse Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Cell Surface Receptor Signaling Pathway Axonogenesis Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration Regulation Of Synapse Assembly Regulation Of Postsynapse Assembly
Pathways		HDL assembly Maturation of spike protein	Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Obesity-related traits ( 23251661)
Interacting Genes		5 interacting genes: MICAL3 MRPL40 PPIL2 RTL10 RTN4R	13 interacting genes: HOXA1 KEAP1 LINGO1 MAG MGAT5B NEK1 NGFR OMG OTX1 PTK7 RTN4 RTN4IP1 ZDHHC8
Entrez ID		29801	65078
HPRD ID		12298	16123
Ensembl ID		ENSG00000099904	ENSG00000040608
Uniprot IDs		Q9ULC8	Q9BZR6
PDB IDs			1OZN 1P8T
Enriched GO Terms of Interacting Partners?		F-actin Monooxygenase Activity Neuregulin Receptor Activity Ganglioside GT1b Binding Ganglioside GM1 Binding	Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Cochlea Morphogenesis Blood Vessel Development Neuron Projection Regeneration Regulation Of Neuron Projection Development Negative Regulation Of Axon Extension Artery Development Semicircular Canal Formation Developmental Process Negative Regulation Of Axonogenesis Nervous System Development Diencephalon Morphogenesis Regulation Of Postsynapse Assembly Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Coreceptor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Abducens Nerve Formation Optokinetic Behavior Mesaxon Regulation Of Cell Projection Organization Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Regulation Of Axon Extension Ganglioside GT1b Binding Death Receptor Activity Metencephalon Development Positive Regulation Of Protein Localization To Endoplasmic Reticulum
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