RTN4R and RTN4

Number of citations of the paper that reports this interaction (PubMedID 11201742)
0

Data Source:
HPRD (in vivo)

		RTN4R	RTN4
Description		reticulon 4 receptor	reticulon 4
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Axon Dendrite Growth Cone Cell Projection Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome Side Of Membrane Glutamatergic Synapse	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Membrane Cell Junction Cell Projection Neuron Projection Neuronal Cell Body Synapse Anchoring Junction Endoplasmic Reticulum Tubular Network Postsynapse Endoplasmic Reticulum Tubular Network Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Heparin Binding Lipid Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Ganglioside GM1 Binding Ganglioside GT1b Binding	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Axonogenesis Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration Regulation Of Synapse Assembly Regulation Of Postsynapse Assembly	Blastocyst Formation Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Endoplasmic Reticulum Organization Nervous System Development Axonal Fasciculation Brain Development Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia-guided Migration Central Nervous System Vasculogenesis Neuron Differentiation Negative Regulation Of Cell Growth Regulation Of Cell Migration Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Rac Protein Signal Transduction Cell Migration Involved In Vasculogenesis Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Modulation Of Chemical Synaptic Transmission Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Nervous System Development Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Cellular Response To Hypoxia Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Intracellular Sphingolipid Homeostasis Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Postsynapse Assembly Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Neutrophil Migration Positive Regulation Of Macrophage Migration Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Positive Regulation Of Artery Morphogenesis Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Vasculogenesis
Pathways		Axonal growth inhibition (RHOA activation)	Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Obesity-related traits ( 23251661)	Adult body size ( 32376654) Fasting glucose ( 34074324) Lymphocyte count ( 32888494) Obesity (extreme) ( 19553259) Platelet count ( 32888494) Systolic blood pressure ( 30224653 32902719)
Interacting Genes		13 interacting genes: HOXA1 KEAP1 LINGO1 MAG MGAT5B NEK1 NGFR OMG OTX1 PTK7 RTN4 RTN4IP1 ZDHHC8	56 interacting genes: BAIAP2 BCL2 BCL2L1 BDKRB1 CCR4 CERT1 CGREF1 CHMP6 CHRM4 CLN8 CNTNAP1 CRMP1 CYSLTR2 DRD2 ERBB2 ERBB3 ERBB4 F2RL1 FXR2 GLP1R GPR35 HLA-DPB1 HTR2C IPP LAMA4 LINC01554 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 NRXN1 NSD1 OGT PLEKHF2 POT1 PPP1R21 PRR13 RAB33A RNF10 RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 STON1 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21
Entrez ID		65078	57142
HPRD ID		16123	07259
Ensembl ID		ENSG00000040608	ENSG00000115310
Uniprot IDs		Q9BZR6	Q9NQC3
PDB IDs		1OZN 1P8T	2G31 2JV5
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Cochlea Morphogenesis Blood Vessel Development Neuron Projection Regeneration Regulation Of Neuron Projection Development Negative Regulation Of Axon Extension Artery Development Semicircular Canal Formation Developmental Process Negative Regulation Of Axonogenesis Nervous System Development Diencephalon Morphogenesis Regulation Of Postsynapse Assembly Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Coreceptor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Abducens Nerve Formation Optokinetic Behavior Mesaxon Regulation Of Cell Projection Organization Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Regulation Of Axon Extension Ganglioside GT1b Binding Death Receptor Activity Metencephalon Development Positive Regulation Of Protein Localization To Endoplasmic Reticulum	Neuregulin Receptor Activity Membrane Organization Signal Transduction G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Presynapse ERBB3:ERBB2 Complex Glutamatergic Synapse Cell Projection Morphogenesis Dendritic Cell Apoptotic Process Membrane Neuromuscular Process Neuron Differentiation Response To Epidermal Growth Factor Protein Localization To Synapse Regulation Of Synapse Organization ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Rho Protein Signal Transduction ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway BH3 Domain Binding Cell Surface Receptor Signaling Pathway Cell Junction Organization Myelin Sheath Axonogenesis ERBB Signaling Pathway Endosome Neuromuscular Junction Non-canonical Inflammasome Complex Assembly Shelterin Complex Neuronal Signal Transduction Protein Localization To Cell Junction Mitochondrion Organization Cell Junction Assembly Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Projection Morphogenesis Signaling Receptor Activity Myelination Axon Ensheathment Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Establishment Of Localization In Cell Regulation Of ERK1 And ERK2 Cascade GABA-ergic Synapse Positive Regulation Of ERK1 And ERK2 Cascade Ceramide Binding ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway
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