ACD and DBNL

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		ACD	DBNL
Description		ACD shelterin complex subunit and telomerase recruitment factor	drebrin like
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex	Golgi Membrane Ruffle Podosome Extracellular Region Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Dendrite Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Secretory Granule Lumen Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Anchoring Junction Presynapse Postsynapse Glutamatergic Synapse Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	DNA Binding Protein Binding Telomerase Inhibitor Activity Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding	Actin Binding Protein Binding Enzyme Activator Activity Protein Domain Specific Binding Cadherin Binding Actin Filament Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton
	Biological Process	Telomere Maintenance Skeletal System Development Urogenital System Development Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Embryonic Limb Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Segmentation Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Telomere	Adaptive Immune Response Immune System Process Endocytosis Synapse Assembly Rac Protein Signal Transduction Neuron Projection Morphogenesis Membrane Organization Podosome Assembly Postsynaptic Actin Cytoskeleton Organization
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Blood protein levels ( 30072576)
Interacting Genes		65 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA ESRP2 FAM131B FBXW7 FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790	14 interacting genes: ACD CASP3 HOMER1 MAP4K1 NEURL4 OGT POT1 SH2D4A SH3BP2 SHANK3 SYK TERF1 TERF2IP ZAP70
Entrez ID		65057	28988
HPRD ID		12417	06588
Ensembl ID		ENSG00000102977	ENSG00000136279
Uniprot IDs		A0A8Q3WM11 Q96AP0	B4DUF9 Q9UJU6
PDB IDs		2I46 5H65 5I2X 5I2Y 5UN7 5XYF 7QXA 7QXB 7QXS 7S1T 7TRE 8SOJ 8SOK	1X67
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Cadherin Binding Carbohydrate Catabolic Process Nuclear Telomere Cap Complex Protein Folding Chaperone Complex Substantia Nigra Development ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Glycolytic Process Telomere Maintenance Cellular Response To Heat ADP Metabolic Process Nicotinamide Nucleotide Metabolic Process Nucleoside Diphosphate Catabolic Process Monosaccharide Metabolic Process Ribonucleoside Diphosphate Catabolic Process Unfolded Protein Binding Telomeric D-loop Binding Telomere Assembly Organelle Organization Neural Nucleus Development Pyruvate Metabolic Process Glucose Metabolic Process Telomere Organization Protein Folding Cortical Cytoskeleton Glucose Catabolic Process Telomeric DNA Binding Protein Binding Shelterin Complex Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Cytoskeleton Microtubule Cytoskeleton Organization Nucleoside Diphosphate Metabolic Process Protein Stabilization Chaperone-mediated Autophagy Microtubule Response To Heat Purine Nucleotide Catabolic Process Nitric-oxide Synthase Regulator Activity TPR Domain Binding Hexose Metabolic Process Microtubule Cytoskeleton Intercellular Bridge Telomeric D-loop Disassembly Hsp90 Protein Binding	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Beta Selection Regulation Of Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Phosphotyrosine Residue Binding Phosphatase Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Chromosome, Telomeric Region Negative Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere Neuron Spine Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Maintenance In Response To DNA Damage Positive Regulation Of DNA Metabolic Process T Cell Receptor Complex Positive Regulation Of Signal Transduction Chromosome Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Alpha-beta T Cell Proliferation DNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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