DBNL and MAP4K1

Number of citations of the paper that reports this interaction (PubMedID 10567356)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DBNL	MAP4K1
Description		drebrin like	mitogen-activated protein kinase kinase kinase kinase 1
Image
GO Annotations	Cellular Component	Golgi Membrane Ruffle Podosome Extracellular Region Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Dendrite Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Secretory Granule Lumen Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Anchoring Junction Presynapse Postsynapse Glutamatergic Synapse Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cytoplasm Membrane
	Molecular Function	Actin Binding Protein Binding Enzyme Activator Activity Protein Domain Specific Binding Cadherin Binding Actin Filament Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Adaptive Immune Response Immune System Process Endocytosis Synapse Assembly Rac Protein Signal Transduction Neuron Projection Morphogenesis Membrane Organization Podosome Assembly Postsynaptic Actin Cytoskeleton Organization	Protein Phosphorylation JNK Cascade Cell Population Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		14 interacting genes: ACD CASP3 HOMER1 MAP4K1 NEURL4 OGT POT1 SH2D4A SH3BP2 SHANK3 SYK TERF1 TERF2IP ZAP70	24 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 PPP2CA SHC1 STRN4 SYK TMEM101
Entrez ID		28988	11184
HPRD ID		06588	03583
Ensembl ID		ENSG00000136279	ENSG00000104814
Uniprot IDs		B4DUF9 Q9UJU6	Q92918
PDB IDs		1X67	6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0 7KAC 7L24 7L25 7L26 7M0K 7M0L 7M0M 7R9L 7R9N 7R9P 7R9T 7SIU 8CDW 8CIJ 8EEC 8FH4 8FJZ 8FKO 8PAR 8PAS 8PAU 8XN7 9BI8 9BIK 9BJ1 9CZT 9CZU 9CZW 9CZX 9D00 9H8D 9H8E 9H8F
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Beta Selection Regulation Of Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Phosphotyrosine Residue Binding Phosphatase Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Chromosome, Telomeric Region Negative Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere Neuron Spine Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Maintenance In Response To DNA Damage Positive Regulation Of DNA Metabolic Process T Cell Receptor Complex Positive Regulation Of Signal Transduction Chromosome Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Alpha-beta T Cell Proliferation DNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Ephrin Receptor Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Signal Transduction Positive Regulation Of Immune Response Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Signal Transduction Immune System Process Positive Regulation Of Immune System Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Receptor Tyrosine Kinase Binding Lymphocyte Homeostasis Leukocyte Activation Regulation Of T Cell Activation Leukocyte Homeostasis Lymphocyte Activation Cell Activation Positive Regulation Of Cell Population Proliferation Homeostasis Of Number Of Cells Cytosol Positive Regulation Of Cell Adhesion SH2 Domain Binding Regulation Of Lymphocyte Activation Protein Domain Specific Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway
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