BMP1 and COL5A2

Number of citations of the paper that reports this interaction (PubMedID 11741999)
0

Data Source:
HPRD (in vivo)

		BMP1	COL5A2
Description		bone morphogenetic protein 1	collagen type V alpha 2 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type V Trimer Collagen Type XI Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Cartilage Development Positive Regulation Of Cartilage Development	Skeletal System Development Collagen Fibril Organization Skin Development Animal Organ Development Eye Morphogenesis System Development Cellular Response To Amino Acid Stimulus Negative Regulation Of Endodermal Cell Differentiation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Attachment of bacteria to epithelial cells Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases			Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Myocardial infarction ( 33532862) Waist-to-hip ratio adjusted for BMI ( 28552196)	Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Haemorrhoidal disease ( 33888516) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: ADRA1A CHRD CLIP2 COL1A1 COL5A1 COL5A2 COL7A1 CST7 DST GEM HSPG2 LAMA3 LAMB3 LAMC2 PTPRZ1 TP53 TWSG1 YLPM1	2 interacting genes: BMP1 DDR1
Entrez ID		649	1290
HPRD ID		00209	00366
Ensembl ID		ENSG00000168487	ENSG00000204262
Uniprot IDs		P13497	P05997
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ
Enriched GO Terms of Interacting Partners?		Basement Membrane Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Region Tissue Development Collagen Trimer Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Laminin-5 Complex Endodermal Cell Differentiation Collagen Type XI Trimer Epidermis Development Hemidesmosome Assembly Integrin Binding Skin Development Hemidesmosome Collagen Fibril Organization Regulation Of Developmental Process Platelet-derived Growth Factor Binding Collagen Biosynthetic Process Cell Adhesion Protease Binding Response To Xenobiotic Stimulus Microtubule Plus-end Binding Endoplasmic Reticulum Lumen Developmental Process Microtubule Plus-end Negative Regulation Of Developmental Process Animal Organ Development Anatomical Structure Morphogenesis System Development Extracellular Space Negative Regulation Of Cell Differentiation Heparin Binding Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Junction Assembly Cell Cortex Structural Molecule Activity Cell-substrate Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cell Population Proliferation Cellular Response To Vitamin E Skeletal System Development Integrin Biosynthetic Process Collagen Type VII Trimer Regulation Of Myelination	Smooth Muscle Cell-matrix Adhesion Protein Tyrosine Kinase Collagen Receptor Activity Cell Aggregation Cartilage Condensation Branching Involved In Mammary Gland Duct Morphogenesis Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Regulation Of Extracellular Matrix Disassembly Ear Development Collagen-activated Signaling Pathway Mammary Gland Alveolus Development Wound Healing, Spreading Of Cells Muscle Cell Migration Positive Regulation Of Cartilage Development Lactation Animal Organ Development Dorsal/ventral Pattern Formation Collagen Fibril Organization Extracellular Space Collagen Binding Axon Development Regulation Of Extracellular Matrix Organization Embryo Implantation Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation
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