BMP1 and LAMB3

Number of citations of the paper that reports this interaction (PubMedID 10806203)
0

Data Source:
HPRD (in vitro, in vivo)

		BMP1	LAMB3
Description		bone morphogenetic protein 1	laminin subunit beta 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Cartilage Development Positive Regulation Of Cartilage Development	Cell Adhesion Epidermis Development Cell Differentiation Endodermal Cell Differentiation Brown Fat Cell Differentiation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Myocardial infarction ( 33532862) Waist-to-hip ratio adjusted for BMI ( 28552196)	Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours) ( 26566055)
Interacting Genes		18 interacting genes: ADRA1A CHRD CLIP2 COL1A1 COL5A1 COL5A2 COL7A1 CST7 DST GEM HSPG2 LAMA3 LAMB3 LAMC2 PTPRZ1 TP53 TWSG1 YLPM1	6 interacting genes: BMP1 COL7A1 LAMA3 LAMC2 MDFI THBS1
Entrez ID		649	3914
HPRD ID		00209	01032
Ensembl ID		ENSG00000168487	ENSG00000196878
Uniprot IDs		P13497	A0A0S2Z3R6 Q13751
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ
Enriched GO Terms of Interacting Partners?		Basement Membrane Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Region Tissue Development Collagen Trimer Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Laminin-5 Complex Endodermal Cell Differentiation Collagen Type XI Trimer Epidermis Development Hemidesmosome Assembly Integrin Binding Skin Development Hemidesmosome Collagen Fibril Organization Regulation Of Developmental Process Platelet-derived Growth Factor Binding Collagen Biosynthetic Process Cell Adhesion Protease Binding Response To Xenobiotic Stimulus Microtubule Plus-end Binding Endoplasmic Reticulum Lumen Developmental Process Microtubule Plus-end Negative Regulation Of Developmental Process Animal Organ Development Anatomical Structure Morphogenesis System Development Extracellular Space Negative Regulation Of Cell Differentiation Heparin Binding Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Junction Assembly Cell Cortex Structural Molecule Activity Cell-substrate Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cell Population Proliferation Cellular Response To Vitamin E Skeletal System Development Integrin Biosynthetic Process Collagen Type VII Trimer Regulation Of Myelination	Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Epidermis Development Endodermal Cell Differentiation Cell Adhesion Extracellular Region Collagen Type VII Trimer Developmental Process Extracellular Space Laminin-2 Complex Negative Regulation Of Nitric Oxide Mediated Signal Transduction Collagen V Binding Laminin-5 Complex Laminin-3 Complex Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Tissue Development Heparin Binding Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Hemidesmosome Assembly Negative Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Transforming Growth Factor Beta1 Production Engulfment Of Apoptotic Cell Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Fibrinogen Binding Hemidesmosome Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Fibrinogen Complex Regulation Of Cell Migration Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Antigen Processing And Presentation Blood Coagulation, Fibrin Clot Formation Chronic Inflammatory Response Regulation Of Nitric Oxide Mediated Signal Transduction Cell Differentiation Endoplasmic Reticulum Lumen Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Fibrinolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of CGMP-mediated Signaling Proteoglycan Binding Protein Maturation Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Pattern Specification Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?