COL5A2

Description		collagen type V alpha 2 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type V Trimer Collagen Type XI Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding
	Biological Process	Skeletal System Development Collagen Fibril Organization Skin Development Animal Organ Development Eye Morphogenesis System Development Cellular Response To Amino Acid Stimulus Negative Regulation Of Endodermal Cell Differentiation
Pathways		Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Attachment of bacteria to epithelial cells Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Haemorrhoidal disease ( 33888516) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Novel Interacting Genes		2 novel interacting genes: BMP1 DDR1
Interacting Genes		2 interacting genes: BMP1 DDR1
Entrez ID		1290
HPRD ID		00366
Ensembl ID		ENSG00000204262
Uniprot IDs		P05997
PDB IDs
Enriched GO Terms of Interacting Partners?		Smooth Muscle Cell-matrix Adhesion Protein Tyrosine Kinase Collagen Receptor Activity Cell Aggregation Cartilage Condensation Branching Involved In Mammary Gland Duct Morphogenesis Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Regulation Of Extracellular Matrix Disassembly Ear Development Collagen-activated Signaling Pathway Mammary Gland Alveolus Development Wound Healing, Spreading Of Cells Muscle Cell Migration Positive Regulation Of Cartilage Development Lactation Animal Organ Development Dorsal/ventral Pattern Formation Collagen Fibril Organization Extracellular Space Collagen Binding Axon Development Regulation Of Extracellular Matrix Organization Embryo Implantation Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation
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