ST3GAL3 and NASP

		ST3GAL3	NASP
Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 3	nuclear autoantigenic sperm protein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity	Protein Binding Histone Binding Protein-containing Complex Binding
	Biological Process	Protein Glycosylation Glycosphingolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Via Lactosylceramide Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing	Blastocyst Development DNA Replication Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Male Gonad Development Protein Transport Response To Testosterone CENP-A Containing Chromatin Assembly
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis Glycosphingolipid biosynthesis
Drugs
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 33547301)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		19 interacting genes: ACTG1 CAVIN2 EIF2B3 FBLN5 HDAC5 KCNQ4 KDM4A LASP1 MOB3B NASP PIK3R3 POU3F1 RPL8 RRM2 SCAMP2 TGFB1I1 TTR VTI1A ZBTB5	23 interacting genes: CDC42 FXR2 H1-1 H1-2 H3-3B H3-4 H3-5 H3C10 H3C13 H3C14 H3C4 H3C8 HDAC6 ITSN1 LUC7L2 MTNR1A OGT PTK2 ST3GAL3 TERF2 TERF2IP TIAM1 ULK2
Entrez ID		6487	4678
HPRD ID		05930	04423
Ensembl ID		ENSG00000126091	ENSG00000132780
Uniprot IDs		A0A2R8Y6H4 A0A2R8Y6L4 A0A2R8Y732 A0A2R8YDJ6 Q11203	P49321 Q5T626
PDB IDs			7V1K 7V1L 7V1M 7V6P 7V6Q
Enriched GO Terms of Interacting Partners?			Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Chromosome Protein-containing Complex Organization Protein Heterodimerization Activity Protein-containing Complex Assembly Cellular Component Assembly Chromatin Organization Chromatin Remodeling Chromosome Organization Telomere Organization Nucleosomal DNA Binding Negative Regulation Of DNA Recombination Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA Recombination At Telomere Regulation Of Cellular Component Organization Shelterin Complex Organelle Organization Negative Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process DNA Binding Regulation Of DNA Recombination Protection From Non-homologous End Joining At Telomere Gene Expression Protein-containing Complex Macromolecule Biosynthetic Process Nuclear Telomere Cap Complex Mitophagy Euchromatin Nucleus G-rich Strand Telomeric DNA Binding Chromosome, Telomeric Region Protein Localization To Chromosome, Telomeric Region Nucleoplasm Telomere Capping Autophagy Of Mitochondrion Telomere Maintenance In Response To DNA Damage Negative Regulation Of Chromosome Organization Regulation Of Cell Growth Chromatin DNA Binding Collateral Sprouting Dendritic Spine Morphogenesis Positive Regulation Of Cellular Component Organization RNA-templated DNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telomeric DNA Binding Negative Regulation Of Protein-containing Complex Assembly
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