XPO4 and EIF5A

Number of citations of the paper that reports this interaction (PubMedID 10944119)
73

Data Source:
HPRD (in vitro, in vivo)

		XPO4	EIF5A
Description		exportin 4	eukaryotic translation initiation factor 5A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Synapse
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Small GTPase Binding	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding
	Biological Process	Glycolytic Process Protein Export From Nucleus Protein Transport Positive Regulation Of Protein Export From Nucleus Nuclear Transport	Translation Translational Elongation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			Hypusine synthesis from eIF5A-lysine
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) General cognitive ability ( 29844566) Neuroblastoma or malignant cutaneous melanoma ( 31605138) PR interval ( 30046033 32439900)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Venous thromboembolism ( 31420334)
Interacting Genes		5 interacting genes: EIF5A RAN RNF10 TUBA3C UBQLN1	19 interacting genes: CRX DHPS DOHH GSC2 LBX1 MEI4 MEOX2 PICK1 REL RPL5 SDCBP SENP1 STUB1 SUMO2 TGM2 UBE2I XPO1 XPO4 XRN2
Entrez ID		64328	1984
HPRD ID		18307	02555
Ensembl ID		ENSG00000132953	ENSG00000132507
Uniprot IDs		Q0VG75 Q9C0E2	P63241
PDB IDs			3CPF 5DLQ 8A0E 8Y0W
Enriched GO Terms of Interacting Partners?		Annulate Lamellae Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination Regulation Of Intrinsic Apoptotic Signaling Pathway Nuclear Pore RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Mitotic Cell Cycle RNA Import Into Nucleus Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Translational Termination Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Ribosomal Small Subunit Export From Nucleus Pre-miRNA Binding Ribosomal Large Subunit Export From Nucleus Importin-alpha Family Protein Binding Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Regulation Of Translational Elongation Cellular Response To Mineralocorticoid Stimulus Nuclear Export Signal Receptor Activity Protein Localization To Nucleolus Ribosomal Subunit Export From Nucleus Regulation Of Toll-like Receptor 3 Signaling Pathway	Regulation Of Ubiquitin-dependent Protein Catabolic Process Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nuclear Export Signal Receptor Activity Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Nucleus Nuclear Export DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Deoxyhypusine Synthase Activity Focal Adhesion Interleukin-5 Receptor Complex Regulation Of Protein Catabolic Process Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Monoamine Transport Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of Protein Export From Nucleus Protein Export From Nucleus Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Glutamatergic Neuron Differentiation Peptidyl-lysine Modification To Peptidyl-hypusine Deoxyhypusine Monooxygenase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Spermidine Catabolic Process Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Interleukin-5 Receptor Binding Protein Deamination Cellular Response To Triglyceride Transcription Termination Site Sequence-specific DNA Binding Nuclear Transport Nucleocytoplasmic Transport
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