SRSF3 and GEMIN2

Number of citations of the paper that reports this interaction (PubMedID 9447963)
80

Data Source:
HPRD (two hybrid)

		SRSF3	GEMIN2
Description		serine and arginine rich splicing factor 3	gem nuclear organelle associated protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding Phospholipase Binding Primary MiRNA Binding Protein-RNA Sequence-specific Adaptor Activity Sequence-specific MRNA Binding	Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing MRNA Export From Nucleus RNA Splicing Primary MiRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly MRNA Processing RNA Splicing Protein-containing Complex Assembly
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 33627673) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Vitamin D levels ( 28757204)
Interacting Genes		40 interacting genes: - APP BCL2L13 CHD1 CIRBP CLK3 CNNM3 DUX4 EXOSC6 FOXP1 GEMIN2 HMGB1 HNRNPK IL7R LNX1 NXF1 PCBP1 PCBP2 PCBP3 PCDHB14 PRPF31 RBM3 RBM7 RBMY1A1 RNF10 RNPS1 RPL9 SCAF11 SDCBP SREK1 SRPK1 SRPK2 SRSF2 SRSF8 TRA2B U2AF1 U2AF2 YWHAB YWHAG YWHAQ	34 interacting genes: AKAP6 BEND7 DDX20 DHX9 FBXO7 GEMIN5 HOXD10 IKBKG INCA1 KPNA6 MEOX1 MTNR1A NUFIP1 PAX6 PSMB1 RN7SL1 RNU1-1 RNU2-1 RPP14 SMN1 SMN2 SNRNP70 SNRPD1 SNRPD2 SNRPD3 SNRPN SPG21 SRSF1 SRSF2 SRSF3 SRSF4 STXBP2 STXBP3 U2AF2
Entrez ID		6428	8487
HPRD ID		04530	03999
Ensembl ID		ENSG00000112081	ENSG00000092208
Uniprot IDs		B2R6F3 P84103	A0A8J9FJK1 A0A8J9FN78 O14893
PDB IDs		2I2Y 2I38 9ASQ	2LEH 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Processing RNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex RNA Processing Nucleus Nuclear Speck Nucleoplasm Nucleic Acid Metabolic Process MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Splicing Spliceosomal Complex Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Viral RNA Genome Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Viral Genome Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of Biosynthetic Process Focal Adhesion Negative Regulation Of RNA Metabolic Process 14-3-3 Protein Binding Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Protein Domain Specific Binding Ribonucleoprotein Complex	RNA Splicing MRNA Processing SMN-Sm Protein Complex Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process Spliceosomal SnRNP Assembly RNA Metabolic Process MRNA Splicing, Via Spliceosome U1 SnRNP Spliceosomal Complex Assembly RNA Binding U2 SnRNP SMN Complex U4 SnRNP Nucleoplasm Nucleic Acid Metabolic Process Gemini Of Cajal Bodies Regulation Of MRNA Processing Small Nuclear Ribonucleoprotein Complex Protein-containing Complex Assembly Spliceosomal Complex U5 SnRNP Commitment Complex Regulation Of MRNA Splicing, Via Spliceosome PICln-Sm Protein Complex Protein-containing Complex Organization Nucleobase-containing Compound Metabolic Process 7-methylguanosine Cap Hypermethylation MRNA Binding Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Regulation Of RNA Splicing Methylosome Sequence-specific MRNA Binding Regulation Of MRNA Metabolic Process Nucleus U2-type Prespliceosome Nuclear Body DNA-templated Transcription Termination Precatalytic Spliceosome Ribonucleoprotein Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Tertiary Granule Nucleic Acid Binding Cellular Response To Cytokine Stimulus U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Cytoplasmic Ribonucleoprotein Granule
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