TFB2M and POLRMT

Number of citations of the paper that reports this interaction (PubMedID 12068295)
0

Data Source:
HPRD (in vitro)

		TFB2M	POLRMT
Description		transcription factor B2, mitochondrial	RNA polymerase mitochondrial
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid	DNA-directed RNA Polymerase Complex Mitochondrion Mitochondrial Matrix Protein-containing Complex Mitochondrial DNA-directed RNA Polymerase Complex Mitochondrial Nucleoid
	Molecular Function	RRNA (adenine-N6,N6-)-dimethyltransferase Activity RNA Binding Methyltransferase Activity RRNA (adenine-N6-)-methyltransferase Activity Transferase Activity Mitochondrial Transcription Factor Activity	3'-5'-RNA Exonuclease Activity Mitochondrial Promoter Sequence-specific DNA Binding DNA Binding RNA Binding DNA-directed RNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity 5'-3' RNA Polymerase Activity Sequence-specific DNA Binding
	Biological Process	RRNA Modification RRNA Processing Mitochondrial Transcription Transcription Initiation At Mitochondrial Promoter RRNA Methylation Methylation	Mitochondrial DNA Replication DNA-templated Transcription Mitochondrial Transcription Transcription Initiation At Mitochondrial Promoter
Pathways		Mitochondrial transcription initiation Transcriptional activation of mitochondrial biogenesis	Mitochondrial transcription initiation Transcriptional activation of mitochondrial biogenesis Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) hemolysis of donated blood (osmotic) ( 34014839) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: MUC1 PNP POLRMT TFAM	3 interacting genes: TFB1M TFB2M UBC
Entrez ID		64216	5442
HPRD ID		09520	03468
Ensembl ID		ENSG00000162851	ENSG00000099821
Uniprot IDs		Q9H5Q4	O00411 Q4G0F4
PDB IDs		6ERO 6ERP 6ERQ	3SPA 4BOC 5OLA 6ERP 6ERQ 7A8P 7PZP 7PZR 7ZC4 8U8U 8U8V 9BDC 9BDD
Enriched GO Terms of Interacting Partners?		Mitochondrial Promoter Sequence-specific DNA Binding Transcription Initiation At Mitochondrial Promoter Mitochondrial Transcription Mitochondrial Nucleoid Mitochondrial RNA Metabolic Process DNA-templated Transcription Initiation Purine-nucleoside Phosphorylase Activity Purine Nucleobase Binding Urate Biosynthetic Process Nicotinamide Riboside Catabolic Process Guanosine Phosphorylase Activity Inosine Catabolic Process Deoxyinosine Catabolic Process Mitochondrial DNA-directed RNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Nucleoside Binding Deoxyadenosine Catabolic Process DAMP Catabolic Process Mitochondrial Transcription Factor Activity Purine Ribonucleoside Catabolic Process Purine Deoxyribonucleoside Metabolic Process IMP Catabolic Process Deoxyribonucleoside Catabolic Process Pentosyltransferase Activity Purine Ribonucleoside Salvage Purine Nucleoside Catabolic Process 5'-3' RNA Polymerase Activity Allantoin Metabolic Process Urate Metabolic Process Negative Regulation Of Cell Adhesion Mediated By Integrin Phosphate Ion Binding Nucleoside Salvage Purine Nucleoside Monophosphate Catabolic Process Mitochondrial DNA Replication Negative Regulation Of Transcription By Competitive Promoter Binding Nucleobase-containing Small Molecule Catabolic Process Deoxyribonucleoside Monophosphate Catabolic Process Mitochondrial Matrix Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling DNA-templated Transcription Mitotic G1/S Transition Checkpoint Signaling IMP Metabolic Process Sequence-specific DNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitochondrial DNA Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Purine Nucleoside Metabolic Process Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process	RRNA (adenine-N6,N6-)-dimethyltransferase Activity Mitochondrial Transcription Factor Activity Transcription Initiation At Mitochondrial Promoter RRNA Methylation RRNA Modification Mitochondrial RNA Metabolic Process Mitochondrial Nucleoid DNA-templated Transcription Initiation RNA Methylation Macromolecule Methylation RNA Modification Methyltransferase Activity Methylation RRNA Processing RRNA (adenine-N6-)-methyltransferase Activity RRNA Metabolic Process RNA Binding Mitochondrion Mitochondrial Transcription Mitochondrial Matrix Protein Tag Activity S-adenosyl-L-methionine Binding RNA Processing Nucleobase-containing Compound Biosynthetic Process Endocytic Vesicle Membrane RNA Metabolic Process Macromolecule Biosynthetic Process Macromolecule Metabolic Process
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