TFB2M and PNP

Number of citations of the paper that reports this interaction (PubMedID 12068295)
0

Data Source:
HPRD (in vitro)

		TFB2M	PNP
Description		transcription factor B2, mitochondrial	purine nucleoside phosphorylase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	RRNA (adenine-N6,N6-)-dimethyltransferase Activity RNA Binding Methyltransferase Activity RRNA (adenine-N6-)-methyltransferase Activity Transferase Activity Mitochondrial Transcription Factor Activity	Nucleoside Binding Purine Nucleobase Binding Catalytic Activity Purine-nucleoside Phosphorylase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity Phosphate Ion Binding Identical Protein Binding Guanosine Phosphorylase Activity
	Biological Process	RRNA Modification RRNA Processing Mitochondrial Transcription Transcription Initiation At Mitochondrial Promoter RRNA Methylation Methylation	Allantoin Metabolic Process Nucleobase-containing Compound Metabolic Process Inosine Catabolic Process Deoxyinosine Catabolic Process Deoxyadenosine Catabolic Process Purine Ribonucleoside Salvage IMP Catabolic Process Nicotinamide Riboside Catabolic Process Immune Response Nucleoside Metabolic Process Nucleotide Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Interleukin-2 Production Urate Biosynthetic Process Positive Regulation Of T Cell Proliferation Purine-containing Compound Salvage DAMP Catabolic Process Positive Regulation Of Alpha-beta T Cell Differentiation
Pathways		Mitochondrial transcription initiation Transcriptional activation of mitochondrial biogenesis	Neutrophil degranulation Purine salvage Purine catabolism Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine Ribavirin ADME
Drugs			Cladribine Didanosine 8-azaguanine 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine Immucillin-G Guanine 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One Peldesine 9-deazainosine Guanosine Ribose-1-Phosphate (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidinium 3'-deoxyguanosine (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium Hypoxanthine 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine Inosine 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE Forodesine
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Bipolar disorder ( 31043756) hemolysis of donated blood (osmotic) ( 34014839) Metabolite levels ( 23823483)	Alanine aminotransferase levels ( 33547301 34315874) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Menopause (age at onset) ( 26414677)
Interacting Genes		4 interacting genes: MUC1 PNP POLRMT TFAM	13 interacting genes: APLP1 CCDC90B CEBPA CFTR LRIF1 NCALD NOS1AP RBM48 TFAM TFB2M TP53 UCHL5 ZHX1
Entrez ID		64216	4860
HPRD ID		09520	01247
Ensembl ID		ENSG00000162851	ENSG00000198805
Uniprot IDs		Q9H5Q4	P00491
PDB IDs		6ERO 6ERP 6ERQ	1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA 5ETJ 5UGF 7ZSL 7ZSM 7ZSN 7ZSO 7ZSP
Enriched GO Terms of Interacting Partners?		Mitochondrial Promoter Sequence-specific DNA Binding Transcription Initiation At Mitochondrial Promoter Mitochondrial Transcription Mitochondrial Nucleoid Mitochondrial RNA Metabolic Process DNA-templated Transcription Initiation Purine-nucleoside Phosphorylase Activity Purine Nucleobase Binding Urate Biosynthetic Process Nicotinamide Riboside Catabolic Process Guanosine Phosphorylase Activity Inosine Catabolic Process Deoxyinosine Catabolic Process Mitochondrial DNA-directed RNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Nucleoside Binding Deoxyadenosine Catabolic Process DAMP Catabolic Process Mitochondrial Transcription Factor Activity Purine Ribonucleoside Catabolic Process Purine Deoxyribonucleoside Metabolic Process IMP Catabolic Process Deoxyribonucleoside Catabolic Process Pentosyltransferase Activity Purine Ribonucleoside Salvage Purine Nucleoside Catabolic Process 5'-3' RNA Polymerase Activity Allantoin Metabolic Process Urate Metabolic Process Negative Regulation Of Cell Adhesion Mediated By Integrin Phosphate Ion Binding Nucleoside Salvage Purine Nucleoside Monophosphate Catabolic Process Mitochondrial DNA Replication Negative Regulation Of Transcription By Competitive Promoter Binding Nucleobase-containing Small Molecule Catabolic Process Deoxyribonucleoside Monophosphate Catabolic Process Mitochondrial Matrix Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling DNA-templated Transcription Mitotic G1/S Transition Checkpoint Signaling IMP Metabolic Process Sequence-specific DNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitochondrial DNA Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Purine Nucleoside Metabolic Process Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process	Mitochondrial Transcription Factor Activity Transcription Initiation At Mitochondrial Promoter Mitochondrial Transcription Nuclear Matrix RNA Metabolic Process Nucleic Acid Metabolic Process DNA-templated Transcription Negative Regulation Of Stem Cell Proliferation 14-3-3 Protein Binding Alpha-2B Adrenergic Receptor Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Transcription Coactivator Binding Mitochondrial Nucleoid Mitochondrial RNA Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nucleobase-containing Compound Metabolic Process Cytosolic MRNA Polyadenylation Alpha-2C Adrenergic Receptor Binding Positive Regulation Of DNA-templated Transcription Initiation CHOP-C/EBP Complex Stem Cell Proliferation Regulation Of Stem Cell Proliferation Cellular Response To Xenobiotic Stimulus Regulation Of DNA-templated Transcription Initiation Protein-containing Complex Protein Heterodimerization Activity Response To Vitamin B2 C/EBP Complex Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Mitochondrial Promoter Sequence-specific DNA Binding DNA-templated Transcription Initiation Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential RRNA (adenine-N6-)-methyltransferase Activity RRNA (adenine-N6,N6-)-dimethyltransferase Activity Cellular Response To Norepinephrine Stimulus
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