IFIH1 and USP3

Number of citations of the paper that reports this interaction (PubMedID 24366338)
39

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		IFIH1	USP3
Description		interferon induced with helicase C domain 1	ubiquitin specific peptidase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytoplasmic Ribonucleoprotein Granule Flemming Body
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Pattern Recognition Receptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2B Deubiquitinase Activity Histone H2A Deubiquitinase Activity
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Detection Of Virus Response To Virus Protein Sumoylation Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production MDA-5 Signaling Pathway Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Complex Oligomerization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Cellular Response To Virus Antiviral Innate Immune Response	DNA Repair Chromatin Organization Proteolysis DNA Damage Response Protein Deubiquitination DNA Repair-dependent Chromatin Remodeling
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses Modulation of host responses by IFN-stimulated genes	Ub-specific processing proteases
Drugs
Diseases		Type I diabetes mellitus
GWAS		Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) HDL cholesterol levels ( 32203549) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Psoriasis ( 23143594 25903422 25574825 20953190) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 26502338 28714469 27399966 19838195) Type 1 diabetes ( 17554260 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494)	A body shape index ( 34021172) Aortic root size ( 28394258) Atrial fibrillation ( 29892015) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Heart failure ( 20445134) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum immune biomarker levels ( 32066700) Triglyceride levels ( 32203549) Type 2 diabetes ( 30054458 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: APP CCDC50 GPD2 KEAP1 RNF10 RNF135 TRIM40 TRIM65 USP3 ZCCHC3	6 interacting genes: CHEK1 IFIH1 PYCARD RIGI TP53 UBC
Entrez ID		64135	9960
HPRD ID		09507	05290
Ensembl ID		ENSG00000115267	ENSG00000140455
Uniprot IDs		Q9BYX4	Q6JHV3 Q9Y6I4
PDB IDs		2RQB 3B6E 3GA3 4GL2 7DNI 7DNJ 7JL0 7JL2
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Innate Immune Response Positive Regulation Of Type I Interferon Production Protein Modification By Small Protein Conjugation Defense Response To Symbiont Defense Response To Other Organism Ubiquitin Protein Ligase Activity Regulation Of Type I Interferon Production Metal Ion Binding Protein Modification Process Positive Regulation Of Cytokine Production Response To Other Organism Positive Regulation Of Interferon-beta Production Immune Response Protein Metabolic Process Protein Ubiquitination Zinc Ion Binding Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Response To External Biotic Stimulus Glycerol-3-phosphate Dehydrogenase (quinone) Activity Protein Polyubiquitination Defense Response To Virus Regulation Of Interferon-beta Production Protein K63-linked Ubiquitination Regulation Of Cytokine Production Regulation Of Defense Response Antiviral Innate Immune Response Acetylcholine Receptor Activator Activity Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Glycerol-3-phosphate Shuttle Response To Virus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Multicellular Organismal Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development	MRNA Transcription Pattern Recognition Receptor Activity Detection Of Virus Regulation Of Interferon-beta Production Regulation Of Type III Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type I Interferon Production Replicative Senescence Cellular Response To Exogenous DsRNA Regulation Of Interleukin-6 Production Innate Immune Response-activating Signaling Pathway Cellular Response To DsRNA Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Interferon-alpha Production Activation Of Innate Immune Response Replication Fork Positive Regulation Of Defense Response To Virus By Host Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intracellular Signal Transduction Protein Complex Oligomerization Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Defense Response To Virus Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Defense Response To Virus By Host Ubiquitin Protein Ligase Binding Positive Regulation Of Innate Immune Response Response To DsRNA Single-stranded RNA Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Immune Response-activating Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Defense Response To Virus Response To Virus Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Response To Osmotic Stress Double-stranded RNA Binding RNA Helicase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Activation Of Immune Response
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