USP3

Description		ubiquitin specific peptidase 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytoplasmic Ribonucleoprotein Granule Flemming Body
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2B Deubiquitinase Activity Histone H2A Deubiquitinase Activity
	Biological Process	DNA Repair Chromatin Organization Proteolysis DNA Damage Response Protein Deubiquitination DNA Repair-dependent Chromatin Remodeling
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS		A body shape index ( 34021172) Aortic root size ( 28394258) Atrial fibrillation ( 29892015) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Heart failure ( 20445134) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum immune biomarker levels ( 32066700) Triglyceride levels ( 32203549) Type 2 diabetes ( 30054458 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		6 novel interacting genes: CHEK1 IFIH1 PYCARD RIGI TP53 UBC
Interacting Genes		6 interacting genes: CHEK1 IFIH1 PYCARD RIGI TP53 UBC
Entrez ID		9960
HPRD ID		05290
Ensembl ID		ENSG00000140455
Uniprot IDs		Q6JHV3 Q9Y6I4
PDB IDs
Enriched GO Terms of Interacting Partners?		MRNA Transcription Pattern Recognition Receptor Activity Detection Of Virus Regulation Of Interferon-beta Production Regulation Of Type III Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type I Interferon Production Replicative Senescence Cellular Response To Exogenous DsRNA Regulation Of Interleukin-6 Production Innate Immune Response-activating Signaling Pathway Cellular Response To DsRNA Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Interferon-alpha Production Activation Of Innate Immune Response Replication Fork Positive Regulation Of Defense Response To Virus By Host Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intracellular Signal Transduction Protein Complex Oligomerization Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Defense Response To Virus Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Defense Response To Virus By Host Ubiquitin Protein Ligase Binding Positive Regulation Of Innate Immune Response Response To DsRNA Single-stranded RNA Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Immune Response-activating Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Defense Response To Virus Response To Virus Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Response To Osmotic Stress Double-stranded RNA Binding RNA Helicase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Activation Of Immune Response
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