IFIH1 and TRIM40

Number of citations of the paper that reports this interaction (PubMedID 29117565)
0

Data Source:
BioGRID (enzymatic study)

		IFIH1	TRIM40
Description		interferon induced with helicase C domain 1	tripartite motif containing 40
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Cytoplasm IkappaB Kinase Complex
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Pattern Recognition Receptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Detection Of Virus Response To Virus Protein Sumoylation Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production MDA-5 Signaling Pathway Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Complex Oligomerization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Cellular Response To Virus Antiviral Innate Immune Response	Negative Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Innate Immune Response Protein Neddylation Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses Modulation of host responses by IFN-stimulated genes
Drugs
Diseases		Type I diabetes mellitus
GWAS		Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) HDL cholesterol levels ( 32203549) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Psoriasis ( 23143594 25903422 25574825 20953190) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 26502338 28714469 27399966 19838195) Type 1 diabetes ( 17554260 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494)	Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 27863252 32888494) Neuroticism ( 29255261) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: APP CCDC50 GPD2 KEAP1 RNF10 RNF135 TRIM40 TRIM65 USP3 ZCCHC3	3 interacting genes: APP IFIH1 RIGI
Entrez ID		64135	135644
HPRD ID		09507	15557
Ensembl ID		ENSG00000115267	ENSG00000204614
Uniprot IDs		Q9BYX4	A0A0G2JIV5 A0A0G2JMU7 A0A1U9X8U1 Q6P9F5
PDB IDs		2RQB 3B6E 3GA3 4GL2 7DNI 7DNJ 7JL0 7JL2
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Innate Immune Response Positive Regulation Of Type I Interferon Production Protein Modification By Small Protein Conjugation Defense Response To Symbiont Defense Response To Other Organism Ubiquitin Protein Ligase Activity Regulation Of Type I Interferon Production Metal Ion Binding Protein Modification Process Positive Regulation Of Cytokine Production Response To Other Organism Positive Regulation Of Interferon-beta Production Immune Response Protein Metabolic Process Protein Ubiquitination Zinc Ion Binding Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Response To External Biotic Stimulus Glycerol-3-phosphate Dehydrogenase (quinone) Activity Protein Polyubiquitination Defense Response To Virus Regulation Of Interferon-beta Production Protein K63-linked Ubiquitination Regulation Of Cytokine Production Regulation Of Defense Response Antiviral Innate Immune Response Acetylcholine Receptor Activator Activity Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Glycerol-3-phosphate Shuttle Response To Virus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Multicellular Organismal Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development	Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Type III Interferon Production Detection Of Virus Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Cellular Response To Exogenous DsRNA Cellular Response To DsRNA Positive Regulation Of Interferon-alpha Production Regulation Of Innate Immune Response Pattern Recognition Receptor Activity Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Positive Regulation Of Defense Response Response To DsRNA Single-stranded RNA Binding Positive Regulation Of Cytokine Production MRNA Transcription Regulation Of Interferon-beta Production Positive Regulation Of Response To Cytokine Stimulus Innate Immune Response Double-stranded RNA Binding RNA Helicase Activity Antiviral Innate Immune Response Defense Response To Symbiont Positive Regulation Of Type I Interferon Production Defense Response To Other Organism Regulation Of Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Defense Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Helicase Activity Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Response To Other Organism Pattern Recognition Receptor Signaling Pathway Acetylcholine Receptor Activator Activity Immune Response Positive Regulation Of Gene Expression Lipoprotein Particle Positive Regulation Of Protein Import Innate Immune Response-activating Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury
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