NOD2 and CNOT1

		NOD2	CNOT1
Description		nucleotide binding oligomerization domain containing 2	CCR4-NOT transcription complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Vesicle Protein-containing Complex Phagocytic Vesicle	P-body Extracellular Space Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Nucleotide Binding Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Pattern Recognition Receptor Activity Peptidoglycan Binding Ubiquitin Binding Anion Binding ADP Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding Carbohydrate Derivative Binding	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Nuclear Estrogen Receptor Binding Nuclear Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding
	Biological Process	Temperature Homeostasis Pattern Recognition Receptor Signaling Pathway Adaptive Immune Response Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Autophagy Defense Response Canonical NF-kappaB Signal Transduction Response To Nutrient Positive Regulation Of Cell Population Proliferation Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Intestinal Stem Cell Homeostasis P38MAPK Cascade Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Host-mediated Modulation Of Intestinal Microbiota Composition Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Protein Linear Polyubiquitination Antibacterial Innate Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mitophagy Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Macrophage Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs		Mifamurtide
Diseases		Crohn's disease Blau syndrome
GWAS		Asthma ( 32296059 31361310 30929738) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17804789 28067908 23128233 22936669 22412388 21102463 20570966 18587394 17554300) Inflammatory bowel disease ( 28067908 18758464) Leprosy ( 25642632 27976721 20018961) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)	Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) PR interval ( 32439900) Pulse pressure ( 30224653) QT interval ( 30679814 19305408 29874175 24952745 22726844) Schizophrenia ( 30285260 29483656 25056061) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		40 interacting genes: ALPI ANKHD1 ANXA2 ATG16L1 C10orf67 CCL13 CHMP4B CHMP5 CNOT1 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 SETD6 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP	17 interacting genes: AMFR BBS2 CDC42 CEBPA CNOT2 CNOT3 CNOT4 CNOT8 DDX6 HSF4 NANOS3 NOD2 OBI1 PPARG RARA RXRA THRB
Entrez ID		64127	23019
HPRD ID		05810	11999
Ensembl ID		ENSG00000167207	ENSG00000125107
Uniprot IDs		A0A286YF65 Q9HC29	A5YKK6
PDB IDs			4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA 7VOI 8BFI 8FY3 9FL8
Enriched GO Terms of Interacting Partners?		Response To Muramyl Dipeptide Cellular Response To Muramyl Dipeptide Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Muscle Thin Filament Tropomyosin Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nuclear Migration Response To External Biotic Stimulus Nucleus Localization Stress Fiber Cytosol Pattern Recognition Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Mitotic Spindle Organization Cellular Response To Lipopolysaccharide Innate Immune Response-activating Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Autophagy Autophagosome Maturation Cellular Response To Molecule Of Bacterial Origin C-terminal Protein Lipidation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Activation Of Innate Immune Response Autophagosome Membrane Intracellular Transport Canonical NF-kappaB Signal Transduction P38MAPK Cascade Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Deubiquitination Regulation Of Organelle Organization Vesicle Budding From Membrane Response To Lipid Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Protein Metabolic Process Organelle Localization Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Protein Linear Polyubiquitination Xenophagy Identical Protein Binding Regulation Of Protein Metabolic Process Cellular Localization Endosome Transport Via Multivesicular Body Sorting Pathway Establishment Of Localization In Cell Cellular Response To Oxygen-containing Compound Positive Regulation Of Xenophagy Positive Regulation Of Organelle Organization	CCR4-NOT Complex Negative Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Biosynthetic Process Retinoic Acid Receptor Signaling Pathway CCR4-NOT Core Complex Negative Regulation Of Macromolecule Metabolic Process P-body MRNA Metabolic Process Negative Regulation Of Metabolic Process MRNA Transcription By RNA Polymerase II Cell Differentiation RNA Polymerase II Transcription Regulator Complex Nuclear Receptor Activity MRNA Transcription Negative Regulation Of Gene Expression Cellular Developmental Process RNA Metabolic Process Regulation Of Translation Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process DNA Binding Domain Binding MRNA Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Lipoprotein Transport Myeloid Leukocyte Differentiation Response To Nutrient Hormone-mediated Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Post-transcriptional Regulation Of Gene Expression LBD Domain Binding Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Transcription By RNA Polymerase II Regulatory NcRNA-mediated Gene Silencing Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Macromolecule Catabolic Process Enzyme Binding RNA Catabolic Process Chromatin Nucleic Acid Metabolic Process Protein Autoubiquitination Regulation Of Protein Metabolic Process
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