NOD2 and PPP2R3B

Number of citations of the paper that reports this interaction (PubMedID 27812135)
77

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NOD2	PPP2R3B
Description		nucleotide binding oligomerization domain containing 2	protein phosphatase 2 regulatory subunit B''beta
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Vesicle Protein-containing Complex Phagocytic Vesicle	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol Cilium
	Molecular Function	Nucleotide Binding Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Pattern Recognition Receptor Activity Peptidoglycan Binding Ubiquitin Binding Anion Binding ADP Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding Carbohydrate Derivative Binding	Calcium Ion Binding Protein Binding Protein Phosphatase Regulator Activity Metal Ion Binding
	Biological Process	Temperature Homeostasis Pattern Recognition Receptor Signaling Pathway Adaptive Immune Response Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Autophagy Defense Response Canonical NF-kappaB Signal Transduction Response To Nutrient Positive Regulation Of Cell Population Proliferation Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Intestinal Stem Cell Homeostasis P38MAPK Cascade Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Host-mediated Modulation Of Intestinal Microbiota Composition Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Protein Linear Polyubiquitination Antibacterial Innate Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mitophagy Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Macrophage Apoptotic Process	Protein Dephosphorylation Regulation Of Cell Cycle
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition
Drugs		Mifamurtide
Diseases		Crohn's disease Blau syndrome
GWAS		Asthma ( 32296059 31361310 30929738) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17804789 28067908 23128233 22936669 22412388 21102463 20570966 18587394 17554300) Inflammatory bowel disease ( 28067908 18758464) Leprosy ( 25642632 27976721 20018961) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		40 interacting genes: ALPI ANKHD1 ANXA2 ATG16L1 C10orf67 CCL13 CHMP4B CHMP5 CNOT1 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 SETD6 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP	12 interacting genes: CDC6 DUSP12 HGS NAA10 NOD2 PPP2CA PPP2R1A PPP2R1B SHANK3 SLC6A9 TMEM14B UBC
Entrez ID		64127	28227
HPRD ID		05810	02276
Ensembl ID		ENSG00000167207	ENSG00000167393
Uniprot IDs		A0A286YF65 Q9HC29	Q9Y5P8
PDB IDs			4I5L 4I5N 4MEW
Enriched GO Terms of Interacting Partners?		Response To Muramyl Dipeptide Cellular Response To Muramyl Dipeptide Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Muscle Thin Filament Tropomyosin Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nuclear Migration Response To External Biotic Stimulus Nucleus Localization Stress Fiber Cytosol Pattern Recognition Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Mitotic Spindle Organization Cellular Response To Lipopolysaccharide Innate Immune Response-activating Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Autophagy Autophagosome Maturation Cellular Response To Molecule Of Bacterial Origin C-terminal Protein Lipidation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Activation Of Innate Immune Response Autophagosome Membrane Intracellular Transport Canonical NF-kappaB Signal Transduction P38MAPK Cascade Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Deubiquitination Regulation Of Organelle Organization Vesicle Budding From Membrane Response To Lipid Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Protein Metabolic Process Organelle Localization Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Protein Linear Polyubiquitination Xenophagy Identical Protein Binding Regulation Of Protein Metabolic Process Cellular Localization Endosome Transport Via Multivesicular Body Sorting Pathway Establishment Of Localization In Cell Cellular Response To Oxygen-containing Compound Positive Regulation Of Xenophagy Positive Regulation Of Organelle Organization	Protein Phosphatase Type 2A Complex Meiotic Sister Chromatid Cohesion, Centromeric Protein Serine/threonine Phosphatase Activity Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand INTAC Complex FAR/SIN/STRIPAK Complex Regulation Of Cell Cycle Process RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition T Cell Homeostasis Nuclear RNA Surveillance Homeostasis Of Number Of Cells Cytosol RNA Surveillance Protein Phosphatase Regulator Activity Sister Chromatid Cohesion Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Cycle RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity DNA-templated Transcription Elongation RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Meiotic Spindle Elongation Glycine Secretion, Neurotransmission Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Homeostasis Lateral Plasma Membrane Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Leukocyte Homeostasis Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Organelle Assembly Positive Regulation Of Heme Biosynthetic Process Regulation Of Synaptic Transmission, Glycinergic Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Detection Of Peptidoglycan Guanylate Kinase-associated Protein Clustering Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Protein Tyrosine Phosphatase Activity Spindle Assembly Regulation Of Heme Biosynthetic Process
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