CNOT1 and NANOS3

Number of citations of the paper that reports this interaction (PubMedID 24736845)
47

Data Source:
BioGRID (pull down)

		CNOT1	NANOS3
Description		CCR4-NOT transcription complex subunit 1	nanos C2HC-type zinc finger 3
Image			No pdb structure
GO Annotations	Cellular Component	P-body Extracellular Space Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Nuclear Estrogen Receptor Binding Nuclear Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding	RNA Binding MRNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance	Regulation Of Translation Germ Cell Development Spermatogenesis Negative Regulation Of Translation Cell Differentiation Oogenesis Regulation Of Cell Cycle MRNA Destabilization Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	Specification of primordial germ cells
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) PR interval ( 32439900) Pulse pressure ( 30224653) QT interval ( 30679814 19305408 29874175 24952745 22726844) Schizophrenia ( 30285260 29483656 25056061) Serum alkaline phosphatase levels ( 33547301)	Hand grip strength ( 29691431)
Interacting Genes		17 interacting genes: AMFR BBS2 CDC42 CEBPA CNOT2 CNOT3 CNOT4 CNOT8 DDX6 HSF4 NANOS3 NOD2 OBI1 PPARG RARA RXRA THRB	7 interacting genes: CIB3 CNOT1 IMP3 MLH1 PSMB1 SIAH1 TEKT4
Entrez ID		23019	342977
HPRD ID		11999	19428
Ensembl ID		ENSG00000125107	ENSG00000187556
Uniprot IDs		A5YKK6	P60323
PDB IDs		4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA 7VOI 8BFI 8FY3 9FL8
Enriched GO Terms of Interacting Partners?		CCR4-NOT Complex Negative Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Biosynthetic Process Retinoic Acid Receptor Signaling Pathway CCR4-NOT Core Complex Negative Regulation Of Macromolecule Metabolic Process P-body MRNA Metabolic Process Negative Regulation Of Metabolic Process MRNA Transcription By RNA Polymerase II Cell Differentiation RNA Polymerase II Transcription Regulator Complex Nuclear Receptor Activity MRNA Transcription Negative Regulation Of Gene Expression Cellular Developmental Process RNA Metabolic Process Regulation Of Translation Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process DNA Binding Domain Binding MRNA Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Lipoprotein Transport Myeloid Leukocyte Differentiation Response To Nutrient Hormone-mediated Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Post-transcriptional Regulation Of Gene Expression LBD Domain Binding Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Transcription By RNA Polymerase II Regulatory NcRNA-mediated Gene Silencing Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Macromolecule Catabolic Process Enzyme Binding RNA Catabolic Process Chromatin Nucleic Acid Metabolic Process Protein Autoubiquitination Regulation Of Protein Metabolic Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Meiotic Spindle Midzone Assembly Macromolecule Catabolic Process Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Nuclear-transcribed MRNA Catabolic Process Late Recombination Nodule MRNA Catabolic Process Meiotic Metaphase I Homologous Chromosome Alignment Mpp10 Complex Positive Regulation Of Isotype Switching To IgA Isotypes RNA Catabolic Process Guanine/thymine Mispair Binding MutSalpha Complex Binding Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Regulation Of Mitotic Recombination Mismatch Repair Complex Negative Regulation Of Mitotic Recombination CCR4-NOT Core Complex Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Preribosome Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Armadillo Repeat Domain Binding Telomere Localization Spindle Midzone Assembly Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Catabolic Process Proteasome Core Complex, Beta-subunit Complex Beta-catenin Destruction Complex Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Poly(A)-specific Ribonuclease Activity Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?