GPSM3 and IVD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPSM3	IVD
Description		G protein signaling modulator 3	isovaleryl-CoA dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding GTPase Regulator Activity	Acyl-CoA Dehydrogenase Activity Protein Binding 3-methylbutanoyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Short-chain Fatty Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response	L-leucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Branched-chain Amino Acid Catabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways		G alpha (i) signalling events	Branched-chain amino acid catabolism Isovaleric acidemia
Drugs			Flavin adenine dinucleotide Coenzyme A persulfide
Diseases			Isovaleric acidemia (IVA)
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Atopic dermatitis ( 23042114 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 31453325) Body mass index variance ( 31453325) Estimated glomerular filtration rate ( 31152163) Hip circumference ( 31453325) Hip circumference variance ( 31453325) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) FEV1 ( 30804560) Idiopathic pulmonary fibrosis ( 31710517) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 30804560) Malaria ( 31844061) Metabolic traits ( 21886157) Serum metabolite levels ( 33031748)
Interacting Genes		44 interacting genes: ACMSD ANKRD33 ASB15 BATF2 BMF C9orf57 CHRDL2 COA7 CTAG1A CTAG1B FAM86C1P FGFR3 GATAD2B GNAI1 GNAI2 GNAI3 HELT HIGD2B HRAS HSF2BP IQCE IVD KCNJ5-AS1 KRTAP11-1 KRTAP13-3 KRTAP19-4 MAPK7 MBD3L1 MEOX2 NR0B2 P4HA3 PRR5 RIPK4 RSPO4 SPAG8 SPMIP5 SPRY3 STXBP5L TADA2A TEX11 UFSP1 USHBP1 ZNF20 ZNF581	4 interacting genes: ACTN3 GPSM3 MGAT5B PNMA1
Entrez ID		63940	3712
HPRD ID		13605	09516
Ensembl ID		ENSG00000213654	ENSG00000128928
Uniprot IDs		A0A024RCP6 Q9Y4H4	A0A0A0MT83 A0A0S2Z4K7 P26440
PDB IDs			1IVH 8SGR
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex	Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Negative Regulation Of Relaxation Of Muscle Response To Muscle Inactivity Response To Denervation Involved In Regulation Of Muscle Adaptation Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Bone Mineralization Involved In Bone Maturation Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Negative Regulation Of Oxidative Phosphorylation Muscle Atrophy Negative Regulation Of Cellular Respiration Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Adaptation Response To Inactivity Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Relaxation Of Muscle Positive Regulation Of Striated Muscle Tissue Development Negative Regulation Of Glycolytic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Skeletal Muscle Contraction Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Oxidative Phosphorylation Pseudopodium Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of ATP Metabolic Process Regulation Of Aerobic Respiration Focal Adhesion Assembly GTPase Regulator Activity Bone Morphogenesis Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Cell-substrate Junction Assembly Structural Constituent Of Muscle Regulation Of Striated Muscle Tissue Development Cell-substrate Junction Organization Regulation Of Cellular Respiration Positive Regulation Of Bone Mineralization Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Regulation Of Myotube Differentiation
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