IVD and PNMA1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		IVD	PNMA1
Description		isovaleryl-CoA dehydrogenase	PNMA family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix	Nucleus Nucleolus Cytoplasm
	Molecular Function	Acyl-CoA Dehydrogenase Activity Protein Binding 3-methylbutanoyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Short-chain Fatty Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding	Protein Binding
	Biological Process	L-leucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Branched-chain Amino Acid Catabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase	Inflammatory Response To Antigenic Stimulus Positive Regulation Of Apoptotic Process
Pathways		Branched-chain amino acid catabolism Isovaleric acidemia
Drugs		Flavin adenine dinucleotide Coenzyme A persulfide
Diseases		Isovaleric acidemia (IVA)
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) FEV1 ( 30804560) Idiopathic pulmonary fibrosis ( 31710517) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 30804560) Malaria ( 31844061) Metabolic traits ( 21886157) Serum metabolite levels ( 33031748)
Interacting Genes		4 interacting genes: ACTN3 GPSM3 MGAT5B PNMA1	170 interacting genes: ABHD17A AGTR1 AIRIM ANKRD36BP1 APTX ARHGEF6 ARID5A ASMTL ATP5PO ATP6V1G1 ATXN7 BEX2 BYSL C21orf58 C8orf33 CARHSP1 CBX8 CCDC146 CCDC187 CCDC198 CCDC33 CCNG1 CCP110 CDK18 CFAP53 CFTR CHIC2 CHMP2B CNNM3 COX5B CTNNA3 DAXX DCTN4 EAF2 EHHADH ENKD1 FAM107A FAM110A FAM161A FAM161B FBF1 FBXL18 FEM1C FMNL2 FOXD4L1 FOXD4L3 FXR1 FXR2 GADD45GIP1 GATA1 GEM GPANK1 GPR25 GRAP2 GTPBP10 HAPLN2 HCK HDAC4 HGS HNRNPLL HOXB9 IGFN1 INO80B IVD KANSL1 KAT2B LAGE3 LENG1 LIN37 LMO3 LNX1 LSM2 MAB21L2 MACIR MARK4 MCM7 MED8 METTL17 MRPL10 MRPL11 MRPL23 MSI1 MYO15B MYOZ1 NIF3L1 NPBWR2 NSMF NTAQ1 NUDT16L1 PARD3 PARD6B PCGF6 PER1 PIN1 PIN4 PKN1 PKN3 PNMA5 PNMA6A POLDIP3 POLL POLM PRKAB2 PRKCG PRKCI PRPF18 PRPF31 PSMA1 RAD51D RAPGEF3 RBM41 RPP25 RPP25L RSPH9 RSRC2 RTP5 RUSC1 SCAND1 SCNM1 SDCBP SEMA4C SH2D4A SHC3 SHISA3 SLC25A48 SLIRP SMIM3 SNRPB SNRPB2 SPATC1L SPG7 SSX2IP STAMBPL1 SUV39H2 TASOR2 TCEA2 TCEANC TCL1B TEAD4 TMSB4X TNNI1 TNNT1 TRIM42 TRIM73 TRPV6 TSHZ2 TSPYL4 TTC23 TTC9C TXNDC9 UBQLN1 UBQLN4 URB1-AS1 USP2 VAV2 VBP1 VPS9D1 WDR25 WT1-AS ZC2HC1C ZCCHC12 ZFYVE26 ZG16B ZNF148 ZNF35 ZNF410 ZNF438 ZNF564 ZNF581 ZNF688
Entrez ID		3712	9240
HPRD ID		09516	04926
Ensembl ID		ENSG00000128928	ENSG00000176903
Uniprot IDs		A0A0A0MT83 A0A0S2Z4K7 P26440	Q8ND90
PDB IDs		1IVH 8SGR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Negative Regulation Of Relaxation Of Muscle Response To Muscle Inactivity Response To Denervation Involved In Regulation Of Muscle Adaptation Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Bone Mineralization Involved In Bone Maturation Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Negative Regulation Of Oxidative Phosphorylation Muscle Atrophy Negative Regulation Of Cellular Respiration Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Adaptation Response To Inactivity Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Relaxation Of Muscle Positive Regulation Of Striated Muscle Tissue Development Negative Regulation Of Glycolytic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Skeletal Muscle Contraction Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Oxidative Phosphorylation Pseudopodium Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of ATP Metabolic Process Regulation Of Aerobic Respiration Focal Adhesion Assembly GTPase Regulator Activity Bone Morphogenesis Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Cell-substrate Junction Assembly Structural Constituent Of Muscle Regulation Of Striated Muscle Tissue Development Cell-substrate Junction Organization Regulation Of Cellular Respiration Positive Regulation Of Bone Mineralization Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Regulation Of Myotube Differentiation	Protein Binding Nucleus Diacylglycerol-dependent Serine/threonine Kinase Activity PAR Polarity Complex
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