FAM204A and SMYD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM204A	SMYD1
Description		family with sequence similarity 204 member A	SET and MYND domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm
	Molecular Function	Protein Binding	DNA Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K4 Trimethyltransferase Activity
	Biological Process		Chromatin Remodeling Heart Development Positive Regulation Of Myotube Differentiation Methylation Skeletal Muscle Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription
Pathways			Cardiogenesis
Drugs
Diseases
GWAS		Leisure-time exercise behaviour (age-stratified) ( 30102679) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)	Night sleep phenotypes ( 27126917) Retinal detachment or retinal break ( 31816047)
Interacting Genes		4 interacting genes: FHL2 KDM1A SMYD1 SPANXN2	45 interacting genes: ARID5A BACH2 BHLHE40 C11orf16 CCDC33 CFAP263 CFAP68 CFTR CIMIP2A DISC1 DVL1 FAM204A FAM83A FAM86C1P H3-5 HDAC2 HDAC3 HDHD3 HMG20A HOMEZ KIF16B KRT35 LENG8 MDFI MEOX2 MYH7B NACA NEFL OGDHL PATZ1 POU2AF2 POU6F2 PRR22 RBM4B RSPH6A RUSC1 SNX11 SPAG8 TBRG1 TTC33 USP54 UTP14A WDR77 ZBTB3 ZBTB44
Entrez ID		63877	150572
HPRD ID		12593	06025
Ensembl ID		ENSG00000165669	ENSG00000115593
Uniprot IDs		F2Z2Y3 Q9H8W3	E9PHG3 Q8NB12
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Muscle Cell Development Atrial Cardiac Muscle Cell Development Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of DNA-templated Transcription Heart Trabecula Formation Ventricular Cardiac Muscle Cell Development Negative Regulation Of RNA Biosynthetic Process Histone H3K9 Demethylase Activity Response To Fungicide MRF Binding Positive Regulation Of Cell Size Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein Demethylase Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Repair Complex Positive Regulation Of Myotube Differentiation Histone H3K4 Trimethyltransferase Activity Histone H3K4 Methyltransferase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Transcription Factor Binding Purine Nucleobase Metabolic Process Histone Demethylase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Calcium-mediated Signaling BHLH Transcription Factor Binding Nuclear Androgen Receptor Binding Positive Regulation Of Neuroblast Proliferation Telomeric DNA Binding Histone Methyltransferase Complex Regulation Of Chromatin Organization Cellular Response To Gamma Radiation DNA Repair-dependent Chromatin Remodeling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Neuron Maturation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Calcineurin-NFAT Signaling Cascade Chromatin Remodeling Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Regulation Of Androgen Receptor Signaling Pathway Regulation Of Calcineurin-mediated Signaling	Circadian Regulation Of Gene Expression Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Axonemal A Tubule Inner Sheath Microtubule-based Process Regulation Of Transcription By RNA Polymerase II Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Sperm Flagellum Cilium Movement Involved In Cell Motility Circadian Rhythm Protein Lysine Deacetylase Activity Microtubule-based Movement
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