SMYD1 and RSPH6A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMYD1	RSPH6A
Description		SET and MYND domain containing 1	radial spoke head 6 homolog A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Radial Spoke Radial Spoke Head Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K4 Trimethyltransferase Activity	Protein Binding
	Biological Process	Chromatin Remodeling Heart Development Positive Regulation Of Myotube Differentiation Methylation Skeletal Muscle Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription	Cilium Movement Axoneme Assembly Cilium Assembly Cilium Movement Involved In Cell Motility Sperm Flagellum Assembly Manchette Disassembly
Pathways		Cardiogenesis
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917) Retinal detachment or retinal break ( 31816047)	Arterial stiffness index ( 31235810) Asthma ( 31959851) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Myocardial infarction ( 33532862) Neutrophil percentage of granulocytes ( 27863252) Platelet count ( 32888494)
Interacting Genes		45 interacting genes: ARID5A BACH2 BHLHE40 C11orf16 CCDC33 CFAP263 CFAP68 CFTR CIMIP2A DISC1 DVL1 FAM204A FAM83A FAM86C1P H3-5 HDAC2 HDAC3 HDHD3 HMG20A HOMEZ KIF16B KRT35 LENG8 MDFI MEOX2 MYH7B NACA NEFL OGDHL PATZ1 POU2AF2 POU6F2 PRR22 RBM4B RSPH6A RUSC1 SNX11 SPAG8 TBRG1 TTC33 USP54 UTP14A WDR77 ZBTB3 ZBTB44	2 interacting genes: LMO4 SMYD1
Entrez ID		150572	81492
HPRD ID		06025	09611
Ensembl ID		ENSG00000115593	ENSG00000104941
Uniprot IDs		E9PHG3 Q8NB12	Q9H0K4
PDB IDs
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Axonemal A Tubule Inner Sheath Microtubule-based Process Regulation Of Transcription By RNA Polymerase II Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Sperm Flagellum Cilium Movement Involved In Cell Motility Circadian Rhythm Protein Lysine Deacetylase Activity Microtubule-based Movement	Transcription Corepressor Activity Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Association Neuron Differentiation Positive Regulation Of Myotube Differentiation Histone H3K4 Trimethyltransferase Activity Histone H3K4 Methyltransferase Activity Motor Neuron Axon Guidance Cardiac Septum Development Negative Regulation Of DNA-templated Transcription Cell Differentiation In Spinal Cord Neuron Fate Specification Thymus Development Regulation Of Cell Fate Commitment Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Fate Specification Spinal Cord Motor Neuron Differentiation Ventricular Septum Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Myotube Differentiation Negative Regulation Of RNA Metabolic Process Cell Leading Edge Animal Organ Development Skeletal Muscle Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation Tube Closure Cell Fate Specification Neural Tube Closure Regulation Of Striated Muscle Cell Differentiation Hematopoietic Or Lymphoid Organ Development
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