RRM2 and LPIN1

		RRM2	LPIN1
Description		ribonucleotide reductase regulatory subunit M2	lipin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoside-diphosphate Reductase Complex	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Membrane
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Transcription Coactivator Activity Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity
	Biological Process	Blastocyst Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition	Lipid Metabolic Process Fatty Acid Metabolic Process Triglyceride Mobilization Mitotic Nuclear Membrane Disassembly Fatty Acid Catabolic Process Triglyceride Biosynthetic Process Animal Organ Regeneration Negative Regulation Of Myelination Cellular Response To Insulin Stimulus Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylethanolamine Metabolic Process Phosphatidic Acid Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Phosphatidic Acid Biosynthetic Process
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	Synthesis of PC Synthesis of PE Depolymerization of the Nuclear Lamina Triglyceride biosynthesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Chronotype ( 30696823) Metabolite levels ( 23823483) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Severe insulin-resistant type 2 diabetes ( 34737425)
Interacting Genes		20 interacting genes: ASAP2 BARX1 CDH1 CDK1 DNM1L GCG ITSN2 KAT5 LAPTM4A LPIN1 MGAT4A NPBWR2 PLK3 RRM1 RRM2B SDCBP ST3GAL3 TAF1B TP53 USP12	2 interacting genes: CDK6 RRM2
Entrez ID		6241	23175
HPRD ID		01587	09271
Ensembl ID		ENSG00000171848	ENSG00000134324
Uniprot IDs		P31350	Q14693
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Mitochondrial DNA Metabolic Process Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Transport Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G0 To G1 Transition Golgi Disassembly Regulation Of Mitotic Cell Cycle Positive Regulation Of Establishment Of Protein Localization Signal Transduction In Response To DNA Damage DNA-templated DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Nuclear Membrane Disassembly Mitochondrial DNA Replication Organelle Disassembly Regulation Of Metaphase Plate Congression Regulation Of Cell Cycle Phase Transition Nuclear Membrane Disassembly Regulation Of Protein Transport Regulation Of Cell Cycle Process Positive Regulation Of Protein Localization Regulation Of Cell Cycle 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Membrane Disassembly Positive Regulation Of Intracellular Protein Transport DNA Biosynthetic Process Carbohydrate Derivative Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Triglyceride Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process DNA Damage Response Signal Transduction By P53 Class Mediator DNA Repair Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization Positive Regulation Of Transport Regulation Of Establishment Of Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Cell Cycle Phase Transition Regulation Of Attachment Of Spindle Microtubules To Kinetochore RRNA Transcription Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction By P53 Class Mediator	Cyclin D3-CDK6 Complex Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex FBXO Family Protein Binding Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Ferric Iron Binding Lateral Ventricle Development Regulation Of Cell Cycle Process Type B Pancreatic Cell Development Regulation Of Hematopoietic Stem Cell Differentiation Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization 2'-deoxyribonucleotide Biosynthetic Process Astrocyte Development Regulation Of Monocyte Differentiation Generation Of Neurons Hematopoietic Stem Cell Differentiation Negative Regulation Of Cellular Senescence Dentate Gyrus Development Protein Heterooligomerization Cyclin-dependent Protein Serine/threonine Kinase Activity Blastocyst Development Cyclin Binding Regulation Of Cell Cycle T Cell Differentiation In Thymus Regulation Of Hematopoietic Progenitor Cell Differentiation Cyclin-dependent Protein Kinase Holoenzyme Complex Deoxyribonucleotide Metabolic Process Regulation Of Cellular Senescence Regulation Of Erythrocyte Differentiation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Osteoblast Differentiation Glial Cell Development Regulation Of Stem Cell Differentiation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Nucleoside Diphosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Regulation Of Fibroblast Proliferation
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