RRM2 and BARX1

		RRM2	BARX1
Description		ribonucleotide reductase regulatory subunit M2	BARX homeobox 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoside-diphosphate Reductase Complex	Chromatin Nucleus
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity
	Biological Process	Blastocyst Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Tissue Development Anterior/posterior Pattern Specification Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Endothelial Cell Differentiation Animal Organ Development Spleen Development Digestive System Development
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs		Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Barrett's esophagus ( 24121790) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Esophageal adenocarcinoma ( 24121790) Heel bone mineral density ( 28869591) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Parkinson's disease ( 26227905) Serum folate levels ( 29953918)
Interacting Genes		20 interacting genes: ASAP2 BARX1 CDH1 CDK1 DNM1L GCG ITSN2 KAT5 LAPTM4A LPIN1 MGAT4A NPBWR2 PLK3 RRM1 RRM2B SDCBP ST3GAL3 TAF1B TP53 USP12	6 interacting genes: CYP17A1 HOXD9 MAPK6 RPS6KA3 RRM2 UBC
Entrez ID		6241	56033
HPRD ID		01587	16017
Ensembl ID		ENSG00000171848	ENSG00000131668
Uniprot IDs		P31350	Q9HBU1
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO	2DMT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Mitochondrial DNA Metabolic Process Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Transport Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G0 To G1 Transition Golgi Disassembly Regulation Of Mitotic Cell Cycle Positive Regulation Of Establishment Of Protein Localization Signal Transduction In Response To DNA Damage DNA-templated DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Nuclear Membrane Disassembly Mitochondrial DNA Replication Organelle Disassembly Regulation Of Metaphase Plate Congression Regulation Of Cell Cycle Phase Transition Nuclear Membrane Disassembly Regulation Of Protein Transport Regulation Of Cell Cycle Process Positive Regulation Of Protein Localization Regulation Of Cell Cycle 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Membrane Disassembly Positive Regulation Of Intracellular Protein Transport DNA Biosynthetic Process Carbohydrate Derivative Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Triglyceride Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process DNA Damage Response Signal Transduction By P53 Class Mediator DNA Repair Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization Positive Regulation Of Transport Regulation Of Establishment Of Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Cell Cycle Phase Transition Regulation Of Attachment Of Spindle Microtubules To Kinetochore RRNA Transcription Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction By P53 Class Mediator
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