RPLP1 and MPC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPLP1	MPC2
Description		ribosomal protein lateral stalk subunit P1	mitochondrial pyruvate carrier 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Ribonucleoprotein Complex	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Inner Mitochondrial Membrane Protein Complex
	Molecular Function	Structural Constituent Of Ribosome Protein Binding Protein Kinase Activator Activity Ribonucleoprotein Complex Binding	Protein Binding Identical Protein Binding Pyruvate Transmembrane Transporter Activity
	Biological Process	Cytoplasmic Translation Translation Translational Elongation	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Import Into Mitochondria Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Pyruvate metabolism
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 23770605 24292274 28165464) Male-pattern baldness ( 27182965) Non-response to citalopram or escitalopram and depression ( 27622933)
Interacting Genes		34 interacting genes: ANKRD13B ARF6 ASCC2 ATP5MF BRD7 C11orf58 C15orf39 CDIPT CDK2AP2 CLIC1 CSNK2A1 EEF1A1 GEMIN7 GSK3B LRIF1 MAP1LC3B MPC2 NSF NUDT21 NUDT3 PDCD4 PFDN1 PPP2CB PTN RPA2 RPLP2 RPS6KA6 SAT1 SGO1 SUOX TAB1 TUBB2A UBE2D3 XRCC6	12 interacting genes: APOC1 CIDEB DIABLO MICOS10 NEAT1 RHBDD2 RPLP1 SNX1 SPG21 SYT16 TEX44 TIMM17B
Entrez ID		6176	25874
HPRD ID		01611	08525
Ensembl ID		ENSG00000137818	ENSG00000143158
Uniprot IDs		P05386	O95563
PDB IDs		2LBF 4BEH 4V6X	8YW6 8YW8 8YW9 9KNW 9KNX 9KNY 9MNW 9MNX 9MNY 9MNZ 9MO0
Enriched GO Terms of Interacting Partners?			Very-low-density Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Regulation Of Triglyceride Metabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process
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