MPC2 and TIMM17B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MPC2	TIMM17B
Description		mitochondrial pyruvate carrier 2	translocase of inner mitochondrial membrane 17B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Inner Mitochondrial Membrane Protein Complex	Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Membrane
	Molecular Function	Protein Binding Identical Protein Binding Pyruvate Transmembrane Transporter Activity	Protein Binding Protein Transmembrane Transporter Activity
	Biological Process	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Import Into Mitochondria Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Protein Targeting To Mitochondrion Intracellular Protein Transport Protein Transport Protein Import Into Mitochondrial Matrix
Pathways		Pyruvate metabolism	Mitochondrial protein import Mitochondrial protein import
Drugs
Diseases
GWAS			Type 2 diabetes ( 30718926)
Interacting Genes		12 interacting genes: APOC1 CIDEB DIABLO MICOS10 NEAT1 RHBDD2 RPLP1 SNX1 SPG21 SYT16 TEX44 TIMM17B	10 interacting genes: APP ATE1 CIDEB CREB3 MPC2 RHBDD2 TEX44 TIMM23 TRIM55 TRIM63
Entrez ID		25874	10245
HPRD ID		08525	02218
Ensembl ID		ENSG00000143158	ENSG00000126768
Uniprot IDs		O95563	O60830
PDB IDs		8YW6 8YW8 8YW9 9KNW 9KNX 9KNY 9MNW 9MNX 9MNY 9MNZ 9MO0
Enriched GO Terms of Interacting Partners?		Very-low-density Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Regulation Of Triglyceride Metabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process	Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Intracellular Transport Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Monocyte Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Deacetylase Activity Arginyl-tRNA--protein Transferase Activity Acetylcholine Receptor Activator Activity Response To Interleukin-1 Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Cellular Localization Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Localization In Cell Protein Arginylation Protein K63-linked Ubiquitination Pyruvate Import Into Mitochondria Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mononuclear Cell Migration Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Mitochondrial Inner Membrane Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Pyruvate Transmembrane Transporter Activity
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