RPLP1 and RPLP2

Number of citations of the paper that reports this interaction (PubMedID 10856704)
0

Data Source:
HPRD (two hybrid)

		RPLP1	RPLP2
Description		ribosomal protein lateral stalk subunit P1	ribosomal protein lateral stalk subunit P2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Ribonucleoprotein Complex	Cytoplasm Cytosol Ribosome Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Structural Constituent Of Ribosome Protein Binding Protein Kinase Activator Activity Ribonucleoprotein Complex Binding	Structural Constituent Of Ribosome Protein Binding
	Biological Process	Cytoplasmic Translation Translation Translational Elongation	Cytoplasmic Translation Cytoplasmic Translational Elongation Translation Translational Elongation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 23770605 24292274 28165464) Male-pattern baldness ( 27182965) Non-response to citalopram or escitalopram and depression ( 27622933)	Intraocular pressure ( 29785010) Keratoconus ( 33649486)
Interacting Genes		34 interacting genes: ANKRD13B ARF6 ASCC2 ATP5MF BRD7 C11orf58 C15orf39 CDIPT CDK2AP2 CLIC1 CSNK2A1 EEF1A1 GEMIN7 GSK3B LRIF1 MAP1LC3B MPC2 NSF NUDT21 NUDT3 PDCD4 PFDN1 PPP2CB PTN RPA2 RPLP2 RPS6KA6 SAT1 SGO1 SUOX TAB1 TUBB2A UBE2D3 XRCC6	9 interacting genes: GRK2 LINC00839 MAPK8 PTEN RPLP1 SRPK2 TIMM10B WEE2-AS1 YWHAQ
Entrez ID		6176	6181
HPRD ID		01611	01612
Ensembl ID		ENSG00000137818	ENSG00000177600
Uniprot IDs		P05386	P05387
PDB IDs		2LBF 4BEH 4V6X	1S4J 2JDL 2LBF 2W1O 4BEH 4V6X 5DDZ 5GU4
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Relaxation Of Smooth Muscle Edg-2 Lysophosphatidic Acid Receptor Binding Protein Serine/threonine Kinase Activity Synapse Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Peptidyl-serine Phosphorylation Intracellular Signaling Cassette JUN Phosphorylation Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity 14-3-3 Protein Binding
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