ROBO1 and MYCBP

		ROBO1	MYCBP
Description		roundabout guidance receptor 1	MYC binding protein
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Cell Surface Membrane Axon Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cell Projection	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Brain Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Differentiation Negative Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rho Protein Signal Transduction Tube Development Roundabout Signaling Pathway Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Ventricular Septum Morphogenesis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Regulation Of DNA-templated Transcription Spermatogenesis Positive Regulation Of DNA-templated Transcription
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Carotid plaque burden ( 28282560) Craniofacial microsomia ( 26853712) Diverticular disease ( 30177863) Excessive daytime sleepiness ( 27992416) Facial emotion recognition ( 28608620) Facial emotion recognition (fearful faces) ( 28608620) Femur bone mineral density x serum urate levels interaction ( 34046847) Gamma glutamyl transferase levels ( 33339817) Glomerular filtration rate in chronic kidney disease ( 26420894) HDL cholesterol levels in HIV infection ( 33109212) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Liver enzyme levels (aspartate transaminase) ( 24124411) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Nose size ( 27182965) Protein quantitative trait loci ( 18464913) Refractive error ( 32231278) Schizophrenia ( 33169155 30285260) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Takayasu arteritis ( 25604533) Visceral adipose tissue ( 26480920) Waist-hip index ( 34021172)	Beard thickness ( 26926045) Menopause (age at onset) ( 26414677)
Interacting Genes		11 interacting genes: ABL1 DSCAM MAGEB6 MAPK14 MYCBP ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3	19 interacting genes: AKAP1 ARHGEF40 CFAP91 CFL1 COPS6 CPNE1 CPNE2 CPNE4 DISP3 ERBB3 GDF9 MYC MYCBPAP PTN PTPRF ROBO1 SSRP1 UBC UBE3A
Entrez ID		6091	26292
HPRD ID		03890	08406
Ensembl ID		ENSG00000169855	ENSG00000214114
Uniprot IDs		Q1RMC8 Q9Y6N7	Q99417
PDB IDs		2EO9 2V9Q 2V9R 2V9T 3WIH 4HLJ 5O5G 5O5I 5OPE 6A77 6A78 6A79	2YY0
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Regulation Of Locomotion Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Retinal Ganglion Cell Axon Guidance Regulation Of Cell Junction Assembly Netrin Receptor Binding Nervous System Development System Development Cell Projection Organization Apoptotic Process Involved In Luteolysis Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Regulation Of Axonogenesis Negative Regulation Of Locomotion Regulation Of Synapse Assembly Negative Regulation Of Chemotaxis Regulation Of Negative Chemotaxis Regulation Of Neuron Projection Development Regulation Of Cell Development Roundabout Binding Neuron Projection Development Regulation Of Chemotaxis Anatomical Structure Morphogenesis Netrin-activated Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Axon Extension Negative Regulation Of Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Growth Axon Extension Involved In Axon Guidance Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Developmental Growth Chemotaxis Dendritic Spine Development Negative Regulation Of Synapse Organization Developmental Process Regulation Of Axon Extension Involved In Axon Guidance Pulmonary Valve Morphogenesis Locomotion Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Circulatory System Development Growth Cone Regulation Of Cell Growth Regulation Of Multicellular Organismal Development Regulation Of Anatomical Structure Morphogenesis Regulation Of Nervous System Development Olfactory Bulb Development	Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Calcium-dependent Phospholipid Binding Cellular Response To Calcium Ion Cofilin-actin Rod Regulation Of Developmental Process Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Protein-containing Complex Disassembly Positive Regulation Of Protein Localization To Cell Leading Edge Regulation Of Epithelial Cell Proliferation Developmental Growth Protein-DNA Complex Disassembly Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Regulation Of Neuron Projection Regeneration Neuron Projection Regeneration Regulation Of Axon Regeneration Chondroitin Sulfate Proteoglycan Binding Sperm Entry Positive Regulation Of Golgi Lumen Acidification Cellular Response To Metal Ion Response To Calcium Ion Regulation Of Neuron Projection Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Synaptic Plasticity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Projection Development Negative Regulation Of Postsynaptic Density Organization Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Female Gamete Generation Regulation Of Progesterone Secretion Myc-Max Complex Regulation Of Acinar Cell Proliferation Dendrite Regeneration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Radial Spoke Stalk Developmental Process Involved In Reproduction
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