ROBO1 and SRGAP2

Number of citations of the paper that reports this interaction (PubMedID 11672528)
0

Data Source:
HPRD (two hybrid)

		ROBO1	SRGAP2
Description		roundabout guidance receptor 1	SLIT-ROBO Rho GTPase activating protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Cell Surface Membrane Axon Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cell Projection	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Lamellipodium Cytoplasmic Vesicle Cell Projection Dendritic Spine Dendritic Spine Head Synapse Postsynaptic Membrane Phagocytic Vesicle Glutamatergic Synapse
	Molecular Function	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding	GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Brain Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Differentiation Negative Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rho Protein Signal Transduction Tube Development Roundabout Signaling Pathway Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Ventricular Septum Morphogenesis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Lamellipodium Assembly Involved In Ameboidal Cell Migration Signal Transduction Nervous System Development Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Regulation Of Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of GTPase Activity Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Synapse Assembly Dendritic Spine Development Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Neuron Migration
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs	Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Carotid plaque burden ( 28282560) Craniofacial microsomia ( 26853712) Diverticular disease ( 30177863) Excessive daytime sleepiness ( 27992416) Facial emotion recognition ( 28608620) Facial emotion recognition (fearful faces) ( 28608620) Femur bone mineral density x serum urate levels interaction ( 34046847) Gamma glutamyl transferase levels ( 33339817) Glomerular filtration rate in chronic kidney disease ( 26420894) HDL cholesterol levels in HIV infection ( 33109212) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Liver enzyme levels (aspartate transaminase) ( 24124411) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Nose size ( 27182965) Protein quantitative trait loci ( 18464913) Refractive error ( 32231278) Schizophrenia ( 33169155 30285260) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Takayasu arteritis ( 25604533) Visceral adipose tissue ( 26480920) Waist-hip index ( 34021172)	Asthma ( 32296059) Cholesterol and Triglycerides ( 23031429) Refractive error ( 32231278) Type 2 diabetes ( 30297969)
Interacting Genes		11 interacting genes: ABL1 DSCAM MAGEB6 MAPK14 MYCBP ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3	6 interacting genes: DISC1 EXOC1 FASLG PCNT ROBO1 YWHAG
Entrez ID		6091	23380
HPRD ID		03890	18520
Ensembl ID		ENSG00000169855	ENSG00000266028
Uniprot IDs		Q1RMC8 Q9Y6N7	A0A075B7B5 A0A1S5UZH8 B4DFE5 B7Z3G4 B7ZM87 O75044
PDB IDs		2EO9 2V9Q 2V9R 2V9T 3WIH 4HLJ 5O5G 5O5I 5OPE 6A77 6A78 6A79	2DL8 4RTT 4RUG 5I6J 5I6R 5I7D
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Regulation Of Locomotion Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Retinal Ganglion Cell Axon Guidance Regulation Of Cell Junction Assembly Netrin Receptor Binding Nervous System Development System Development Cell Projection Organization Apoptotic Process Involved In Luteolysis Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Regulation Of Axonogenesis Negative Regulation Of Locomotion Regulation Of Synapse Assembly Negative Regulation Of Chemotaxis Regulation Of Negative Chemotaxis Regulation Of Neuron Projection Development Regulation Of Cell Development Roundabout Binding Neuron Projection Development Regulation Of Chemotaxis Anatomical Structure Morphogenesis Netrin-activated Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Axon Extension Negative Regulation Of Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Growth Axon Extension Involved In Axon Guidance Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Developmental Growth Chemotaxis Dendritic Spine Development Negative Regulation Of Synapse Organization Developmental Process Regulation Of Axon Extension Involved In Axon Guidance Pulmonary Valve Morphogenesis Locomotion Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Circulatory System Development Growth Cone Regulation Of Cell Growth Regulation Of Multicellular Organismal Development Regulation Of Anatomical Structure Morphogenesis Regulation Of Nervous System Development Olfactory Bulb Development	Positive Regulation Of Signal Transduction Positive Regulation Of Phospholipid Translocation Positive Regulation Of Cell Communication Cytoplasmic Vesicle Lumen Perinuclear Region Of Cytoplasm Positive Regulation Of Signaling Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Microtubule Organizing Center Molecular Adaptor Activity Negative Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Roundabout Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration TOR Signaling Protein Kinase C Inhibitor Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Positive Regulation Of Cellular Component Organization Cytoplasm Regulation Of Plasma Membrane Organization Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Intracellular Signal Transduction Signal Transduction Necroptotic Signaling Pathway Inflammatory Cell Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phospholipid Transport Intracellular Chloride Ion Homeostasis Endosomal Lumen Acidification Negative Regulation Of Multicellular Organismal Process Necroptotic Process Regulation Of Developmental Process Microtubule Cell Projection Organization Cilium Assembly Plasma Membrane Bounded Cell Projection Organization Cilium Organization LRR Domain Binding Endocardial Cushion Formation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Heart Induction Positive Regulation Of Neurogenesis Axon Guidance Receptor Activity Axon Choice Point Recognition Positive Regulation Of Nervous System Development
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