ROBO1 and SLIT2

Number of citations of the paper that reports this interaction (PubMedID 10102268)
0

Data Source:
HPRD (in vivo)

		ROBO1	SLIT2
Description		roundabout guidance receptor 1	slit guidance ligand 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Cell Surface Membrane Axon Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cell Projection	Extracellular Region Extracellular Space Cytoplasm Cell Surface Membrane Extracellular Exosome
	Molecular Function	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding	GTPase Inhibitor Activity Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding Protein Homodimerization Activity Laminin-1 Binding Proteoglycan Binding Roundabout Binding
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Brain Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Differentiation Negative Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rho Protein Signal Transduction Tube Development Roundabout Signaling Pathway Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Ventricular Septum Morphogenesis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Ureteric Bud Development Kidney Development Negative Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Leukocyte Chemotaxis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Chemotaxis Nervous System Development Axon Guidance Motor Neuron Axon Guidance Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Olfactory Bulb Development Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Corticospinal Neuron Axon Guidance Through Spinal Cord Telencephalon Cell Migration Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Retinal Ganglion Cell Axon Guidance Regulation Of Cellular Component Size Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Branching Morphogenesis Of An Epithelial Tube Axon Extension Involved In Axon Guidance Regulation Of Neurogenesis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Induction Of Negative Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Response To Cortisol Ventricular Septum Morphogenesis Epithelial Tube Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Heparin Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Mononuclear Cell Migration Circulatory System Development Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs	Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs Formation of the ureteric bud
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Carotid plaque burden ( 28282560) Craniofacial microsomia ( 26853712) Diverticular disease ( 30177863) Excessive daytime sleepiness ( 27992416) Facial emotion recognition ( 28608620) Facial emotion recognition (fearful faces) ( 28608620) Femur bone mineral density x serum urate levels interaction ( 34046847) Gamma glutamyl transferase levels ( 33339817) Glomerular filtration rate in chronic kidney disease ( 26420894) HDL cholesterol levels in HIV infection ( 33109212) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Liver enzyme levels (aspartate transaminase) ( 24124411) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Nose size ( 27182965) Protein quantitative trait loci ( 18464913) Refractive error ( 32231278) Schizophrenia ( 33169155 30285260) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Takayasu arteritis ( 25604533) Visceral adipose tissue ( 26480920) Waist-hip index ( 34021172)	Adiponectin levels x Mediterranean diet adherence interaction ( 33562295) Adult body size ( 32376654) Body mass index ( 31453325) Body mass index variance ( 31453325) Early spontaneous preterm birth ( 31194736) Echocardiographic traits ( 17903301) Gestational age at birth (child effect) ( 31194736) HDL cholesterol levels in HIV infection ( 33109212) Pars orbitalis volume ( 31530798) QRS duration ( 27659466) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		11 interacting genes: ABL1 DSCAM MAGEB6 MAPK14 MYCBP ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3	12 interacting genes: CSDE1 GPC1 HOXA1 OGT PAX8 PDE4B ROBO1 ROBO2 SEL1L3 UBC USP7 ZCCHC4
Entrez ID		6091	9353
HPRD ID		03890	04776
Ensembl ID		ENSG00000169855	ENSG00000145147
Uniprot IDs		Q1RMC8 Q9Y6N7	O94813
PDB IDs		2EO9 2V9Q 2V9R 2V9T 3WIH 4HLJ 5O5G 5O5I 5OPE 6A77 6A78 6A79	2V70 2V9S 2V9T 2WFH
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Regulation Of Locomotion Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Retinal Ganglion Cell Axon Guidance Regulation Of Cell Junction Assembly Netrin Receptor Binding Nervous System Development System Development Cell Projection Organization Apoptotic Process Involved In Luteolysis Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Regulation Of Axonogenesis Negative Regulation Of Locomotion Regulation Of Synapse Assembly Negative Regulation Of Chemotaxis Regulation Of Negative Chemotaxis Regulation Of Neuron Projection Development Regulation Of Cell Development Roundabout Binding Neuron Projection Development Regulation Of Chemotaxis Anatomical Structure Morphogenesis Netrin-activated Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Axon Extension Negative Regulation Of Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Growth Axon Extension Involved In Axon Guidance Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Developmental Growth Chemotaxis Dendritic Spine Development Negative Regulation Of Synapse Organization Developmental Process Regulation Of Axon Extension Involved In Axon Guidance Pulmonary Valve Morphogenesis Locomotion Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Circulatory System Development Growth Cone Regulation Of Cell Growth Regulation Of Multicellular Organismal Development Regulation Of Anatomical Structure Morphogenesis Regulation Of Nervous System Development Olfactory Bulb Development	Artery Development Negative Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Axon Choice Point Recognition Heart Induction Regulation Of Heart Morphogenesis Axon Guidance Receptor Activity Regulation Of Animal Organ Morphogenesis Endocardial Cushion Formation Pulmonary Valve Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Blood Vessel Development Organ Induction Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Translation Outflow Tract Septum Morphogenesis Regulation Of Animal Organ Formation Developmental Induction Aorta Development Aortic Valve Morphogenesis Metanephros Development Ventricular Septum Morphogenesis Positive Regulation Of Notch Signaling Pathway Tube Development Neuron Recognition Mesonephric Epithelium Development Mesonephric Tubule Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Chemotaxis Positive Regulation Of Macromolecule Biosynthetic Process Semicircular Canal Formation Positive Regulation Of Metabolic Process Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Regulation Of Thyroid-stimulating Hormone Secretion Regulation Of Gluconeogenesis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Inner Ear Development Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Positive Regulation Of Gene Expression Positive Regulation Of Developmental Process Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Relaxation Of Cardiac Muscle
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