RBBP7 and SUV39H1

Number of citations of the paper that reports this interaction (PubMedID 11788710)
44

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		RBBP7	SUV39H1
Description		RB binding protein 7, chromatin remodeling factor	SUV39H1 histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol NuRD Complex NURF Complex ESC/E(Z) Complex Sin3-type Complex ATPase Complex	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex Chromosome Nucleolus Plasma Membrane Membrane Cytoplasmic Vesicle RDNA Heterochromatin ENoSc Complex
	Molecular Function	RNA Binding Protein Binding Histone Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Brain Development Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Response To Steroid Hormone Cellular Heat Acclimation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Blastocyst Hatching Regulation Of DNA Repair Chromatin Organization RRNA Processing DNA Damage Response Circadian Rhythm Determination Of Adult Lifespan Cell Differentiation Regulation Of Bone Mineralization Heterochromatin Formation Methylation Regulation Of Multicellular Organism Growth Cellular Response To Glucose Starvation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By Glucose Rhythmic Process Cellular Response To Hypoxia Energy Homeostasis Regulation Of Cellular Senescence
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Neddylation Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression
Drugs
Diseases
GWAS		Refractive error ( 32231278)
Interacting Genes		32 interacting genes: APPL1 APPL2 BRCA1 BRMS1 BRMS1L BUB3 CREBBP CRYAA CYTOR DDB1 DHX30 ERCC6 ESR1 H3-4 H3C1 H4C1 HDAC1 HDAC2 ING1 MBD3 MTA2 NR2E3 PRKAA2 RB1 RBBP4 RBP1 SALL2 SAP30 SIN3A SUMO2 SUV39H1 TWIST1	137 interacting genes: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C4orf17 C8orf74 CBX1 CBX4 CBX5 CDC23 CDCA4 CDCA7L CEP70 CFAP100 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B DVL3 ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GOLGA6L9 GPATCH2L GTF2H2C_2 GTPBP2 H3-3A H3-4 H3-5 H3C1 H3C15 HDAC1 HDAC2 HDAC3 HDAC5 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRT31 KRTAP10-7 KRTAP10-8 LDHAL6B LENG8 LHX8 LINC02875 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 ODAD3 OPA3 PADI6 PHF19 PML PNKP PPP1R16A PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RIN3 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEKT4 TEX35 THRA TMEM11 TNFAIP1 TNS2 TRIM41 U2AF1 WDFY3 WIZ ZBTB2 ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF417 ZNF436 ZNF438 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZRANB1 ZSCAN9
Entrez ID		5931	6839
HPRD ID		04231	02221
Ensembl ID		ENSG00000102054	ENSG00000101945
Uniprot IDs		Q16576 Q6FHQ0	O43463
PDB IDs		3CFS 3CFV 7M3X	3MTS
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Chromatin Remodeling Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Nucleus Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process NuRD Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Histone Deacetylase Complex Regulation Of Gene Expression Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Fate Specification Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Rhythmic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Developmental Process Histone Deacetylase Binding Negative Regulation Of Developmental Process Protein-containing Complex Heterochromatin Formation Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Nucleosomal DNA Binding Chromatin Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Fate Commitment Negative Regulation Of Gene Expression, Epigenetic Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Migration Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Primary Metabolic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of Metabolic Process Heterochromatin Formation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process ESC/E(Z) Complex Chromatin Transcription Corepressor Binding Negative Regulation Of Metabolic Process Histone Deacetylase Complex Transcription Corepressor Activity Promoter-specific Chromatin Binding Negative Regulation Of Gene Expression DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity Chromatin DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Chromosome, Telomeric Region Negative Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Lipid Kinase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?