SUV39H1 and DCAF8

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		SUV39H1	DCAF8
Description		SUV39H1 histone lysine methyltransferase	DDB1 and CUL4 associated factor 8
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex Chromosome Nucleolus Plasma Membrane Membrane Cytoplasmic Vesicle RDNA Heterochromatin ENoSc Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Blastocyst Hatching Regulation Of DNA Repair Chromatin Organization RRNA Processing DNA Damage Response Circadian Rhythm Determination Of Adult Lifespan Cell Differentiation Regulation Of Bone Mineralization Heterochromatin Formation Methylation Regulation Of Multicellular Organism Growth Cellular Response To Glucose Starvation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By Glucose Rhythmic Process Cellular Response To Hypoxia Energy Homeostasis Regulation Of Cellular Senescence	Myotube Cell Development Protein Ubiquitination
Pathways		PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression	Neddylation
Drugs
Diseases
GWAS			Breast size ( 27182965) Lung function (FEV1/FVC) ( 30061609) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		137 interacting genes: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C4orf17 C8orf74 CBX1 CBX4 CBX5 CDC23 CDCA4 CDCA7L CEP70 CFAP100 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B DVL3 ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GOLGA6L9 GPATCH2L GTF2H2C_2 GTPBP2 H3-3A H3-4 H3-5 H3C1 H3C15 HDAC1 HDAC2 HDAC3 HDAC5 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRT31 KRTAP10-7 KRTAP10-8 LDHAL6B LENG8 LHX8 LINC02875 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 ODAD3 OPA3 PADI6 PHF19 PML PNKP PPP1R16A PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RIN3 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEKT4 TEX35 THRA TMEM11 TNFAIP1 TNS2 TRIM41 U2AF1 WDFY3 WIZ ZBTB2 ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF417 ZNF436 ZNF438 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZRANB1 ZSCAN9	17 interacting genes: CRYAA DDB1 GSK3A GTPBP3 MDFI PIK3R3 PRMT1 PRMT8 RAF1 RBM11 RBPMS SPAST SUV39H1 THAP1 TNS2 TRIM54 WDR76
Entrez ID		6839	50717
HPRD ID		02221	18300
Ensembl ID		ENSG00000101945	ENSG00000132716
Uniprot IDs		O43463	B7Z8C9 Q5TAQ9
PDB IDs		3MTS	3I8E
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Primary Metabolic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of Metabolic Process Heterochromatin Formation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process ESC/E(Z) Complex Chromatin Transcription Corepressor Binding Negative Regulation Of Metabolic Process Histone Deacetylase Complex Transcription Corepressor Activity Promoter-specific Chromatin Binding Negative Regulation Of Gene Expression DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity Chromatin DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Chromosome, Telomeric Region Negative Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Lipid Kinase Activity	Epigenetic Programming Of Gene Expression Protein-arginine Omega-N Monomethyltransferase Activity Histone Methyltransferase Activity Peptidyl-arginine Methylation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H4 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Methylation Insulin Receptor Signaling Pathway Epigenetic Programming In The Zygotic Pronuclei Identical Protein Binding Nucleus S-adenosyl-L-methionine Binding Macromolecule Methylation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Viral Protein Processing S-adenosylmethionine-dependent Methyltransferase Activity Viral Process Developmental Process Regulation Of Microtubule Cytoskeleton Organization Enzyme Binding Protein Methylation Methyltransferase Activity Regulation Of Microtubule Depolymerization Cellular Developmental Process Protein-containing Complex Assembly Negative Regulation Of UDP-glucose Catabolic Process Cell Differentiation Protein Homooligomerization GATOR1 Complex Binding Chromatin Organization Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus RNA Processing Regulation Of Macromolecule Metabolic Process Heterochromatin Response To Stress Protein-containing Complex Organization Negative Regulation Of Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Complex Oligomerization Death-inducing Signaling Complex Assembly TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Regulation Of Microtubule-based Process Regulation Of Alternative MRNA Splicing, Via Spliceosome
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