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RB1 and USP4
Number of citations of the paper that reports this interaction (PubMedID
11571651
)
0
Data Source:
HPRD
(in vivo)
RB1
USP4
Description
RB transcriptional corepressor 1
ubiquitin specific peptidase 4
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Spindle
Cytosol
Cyclin/CDK Positive Transcription Elongation Factor Complex
SWI/SNF Complex
PML Body
Rb-E2F Complex
Chromatin Lock Complex
Nucleus
Cytoplasm
Lysosome
Cytosol
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Molecular Adaptor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Importin-alpha Family Protein Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Adenosine Receptor Binding
Identical Protein Binding
Metal Ion Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Growth
Tissue Homeostasis
Chondrocyte Differentiation
Aortic Valve Morphogenesis
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Smoothened Signaling Pathway
Ras Protein Signal Transduction
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Glial Cell Proliferation
Cell Differentiation
Neuron Differentiation
Negative Regulation Of Cell Growth
Sister Chromatid Biorientation
Neuron Projection Development
Heterochromatin Formation
Developmental Process
Cellular Response To Insulin Stimulus
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Striated Muscle Cell Differentiation
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Regulation Of Cell Cycle
Negative Regulation Of Glial Cell Proliferation
Protein Localization To Chromosome, Centromeric Region
Cellular Response To Xenobiotic Stimulus
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Extracellular Matrix Organization
Negative Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Myofibroblast Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Apoptotic Signaling Pathway
Spliceosomal Tri-snRNP Complex Assembly
Cytoplasmic Translation
Proteolysis
Cellular Response To Starvation
Protein Deubiquitination
Negative Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Cellular Response To Nutrient Levels
Protein Localization To Cell Surface
TORC1 Signaling
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RUNX2 regulates osteoblast differentiation
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective translocation of RB1 mutants to the nucleus
Replication of the SARS-CoV-1 genome
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Replication of the SARS-CoV-2 genome
Nuclear events stimulated by ALK signaling in cancer
Positive Regulation of CDH1 Gene Transcription
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Ub-specific processing proteases
Drugs
Diseases
Chronic myeloid leukemia (CML)
Breast cancer
Osteosarcoma
Hepatocellular carcinoma
Small cell lung cancer
Esophageal cancer
Glioma
Bladder cancer
GWAS
Birth weight (
27680694
31043758
)
Chronic kidney disease (
26420894
)
Diastolic blood pressure (
34074324
)
Lymphocyte count (
32888494
)
Offspring birth weight (
31043758
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Glycated hemoglobin levels (
34059833
28898252
)
High light scatter reticulocyte percentage of red cells (
27863252
)
Household income (MTAG) (
31844048
)
Inflammatory bowel disease (
28067908
23128233
)
Intelligence (MTAG) (
29326435
)
Lymphocyte count (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte count (
27863252
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Sleep duration (short sleep) (
30846698
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
25082827
)
Interacting Genes
203 interacting genes:
AATF
ABL1
AHR
ANKS1A
AR
ARID3B
ATF2
BAAT
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX4
CCDC180
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDADC1
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CHN2
CLNK
CNTN3
CORO2A
COX17
CREG1
CRYBA4
CSK
CTBP1
CTSV
CUX1
DGKZ
DNMT1
DVL1
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
ESD
FANCC
FBP1
FBP2
FOS
FOXM1
FRK
FZR1
GALNT12
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
KEAP1
KMT5C
L3MBTL1
LEF1
LIN54
LIN9
LMNA
LRCH1
MAPK1
MAPK14
MAPK3
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MTRF1
MYC
MYOD1
NCF1
NCOA6
NDC80
NEFM
ORC1
PA2G4
PAX2
PAX5
PAX6
PCDHB5
PELP1
PHB1
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PPP1R26
PPP1R9B
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RABGAP1L
RACK1
RAF1
RASA1
RBAK
RBBP4
RBBP5
RBBP6
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF123
RNF40
RUNX2
SERPINB2
SHC1
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
STX17
SUV39H1
TAF1
TASOR
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TRAP1
TRIM27
TRIM28
TRIP11
TRMO
UBE2I
UBTF
USP4
USP7
VDR
XPA
ZBTB16
49 interacting genes:
AKT1
ANXA7
ASS1
ATP1B1
ATP1B3
BDKRB2
BRAP
CDKN1A
CIAO2B
DLC1
HDAC2
IGKV2D-29
IRF4
LAMA5
LGALS1
MAP3K7
NLK
NOLC1
NPC2
PCNA
PDK1
PGM1
PLA2G2A
PLOD1
PPIA
PRPF3
PSAP
PSMA6
PSMC5
PSMD11
RB1
RBBP8
RBL1
RBL2
RCC1
RHEB
RNPS1
SMAD4
SMN1
TK1
TP53BP2
TRAF2
TRIM21
TRIM54
TRIM55
TRIM63
UBC
USP21
USP28
Entrez ID
5925
7375
HPRD ID
01574
04598
Ensembl ID
ENSG00000139687
ENSG00000114316
Uniprot IDs
A0A2R8YFL6
A0A3B3IS71
P06400
Q08AK7
Q13107
PDB IDs
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4CRI
4ELJ
4ELL
9DGK
9DHC
9DHF
9DHU
2Y6E
5CTR
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleus
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Cellular Response To Stress
Regulation Of Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
DNA Damage Response
Chromatin
Chromatin Binding
Positive Regulation Of Transcription By RNA Polymerase II
Nucleic Acid Metabolic Process
Regulation Of Cell Population Proliferation
Regulation Of Programmed Cell Death
DNA-templated Transcription
Regulation Of Apoptotic Process
Macromolecule Metabolic Process
Chromatin Remodeling
Chromatin Organization
Regulation Of Mitotic Cell Cycle
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
DNA Binding
Transcription Cis-regulatory Region Binding
Nucleobase-containing Compound Metabolic Process
Response To Stress
Regulation Of Lipid Kinase Activity
Intracellular Signal Transduction
Nucleoplasm
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Intracellular Signaling Cassette
Macromolecule Metabolic Process
Extracellular Exosome
PCNA-p21 Complex
Regulation Of Kinase Activity
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Response To Stress
Nucleus
Identical Protein Binding
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Regulation Of Phosphorylation
Positive Regulation Of Catalytic Activity
TORC1 Signaling
Regulation Of Cell Cycle
Apoptotic Signaling Pathway
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Deoxyribonuclease Activity
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cell Cycle Phase Transition
Protein-containing Complex
Cytoplasm
Cytosol
Response To External Biotic Stimulus
Negative Regulation Of Cell Cycle
Signal Transduction
Positive Regulation Of Potassium Ion Import Across Plasma Membrane
Sulfate Binding
Cellular Response To Stress
G1/S Transition Of Mitotic Cell Cycle
Regulation Of G1/S Transition Of Mitotic Cell Cycle
TOR Signaling
Cell Cycle G1/S Phase Transition
Positive Regulation Of Sodium Ion Transport
NF-kappaB Binding
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Potassium Ion Import
Cellular Response To Chemical Stress
Protein Modification Process
Negative Regulation Of Cell Cycle Process
Epithelial Cell Differentiation
DNA-binding Transcription Factor Binding
Positive Regulation Of Interleukin-2 Production
Cell Differentiation
Regulation Of Cell Cycle G1/S Phase Transition
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