USP4 and PPIA

Number of citations of the paper that reports this interaction (PubMedID 29396555)
44

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		USP4	PPIA
Description		ubiquitin specific peptidase 4	peptidylprolyl isomerase A
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Vesicle Protein-containing Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Integrin Binding Protein Binding Cyclosporin A Binding Isomerase Activity Virion Binding Unfolded Protein Binding Heparan Sulfate Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Cytoplasmic Translation Proteolysis Cellular Response To Starvation Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Protein Localization To Cell Surface TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Protein Peptidyl-prolyl Isomerization Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Folding Negative Regulation Of Protein Kinase Activity Apoptotic Process Viral Release From Host Cell Platelet Activation Neuron Differentiation Neutrophil Chemotaxis Leukocyte Chemotaxis Activation Of Protein Kinase B Activity Negative Regulation Of Stress-activated MAPK Cascade Lipid Droplet Organization Cellular Response To Oxidative Stress Endothelial Cell Activation Positive Regulation Of MAPK Cascade Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Adhesion Molecule Production Negative Regulation Of Protein K48-linked Ubiquitination Platelet Aggregation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Viral Life Cycle Regulation Of Apoptotic Signaling Pathway
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases	Platelet degranulation Uncoating of the HIV Virion Budding and maturation of HIV virion Integration of provirus Early Phase of HIV Life Cycle Minus-strand DNA synthesis Plus-strand DNA synthesis Binding and entry of HIV virion Assembly Of The HIV Virion APOBEC3G mediated resistance to HIV-1 infection Calcineurin activates NFAT Basigin interactions Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation SARS-CoV-1 activates/modulates innate immune responses
Drugs			Cyclosporine Proline (3r)-1-Acetyl-3-Methylpiperidine Ethyl Oxo(Piperidin-1-Yl)Acetate Sanglifehrin A Copper Artenimol
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)	Mean reticulocyte volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		49 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BDKRB2 BRAP CDKN1A CIAO2B DLC1 HDAC2 IGKV2D-29 IRF4 LAMA5 LGALS1 MAP3K7 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28	30 interacting genes: APP BSG CD99 ERCC6 ERRFI1 G3BP1 GRSF1 ITK JAK2 LIG4 LNX1 N4BP2L2 NOTCH3 PAXIP1 PDE4B PRLR PRR13 PRSS23 PTPRN RB1 S100A8 SRPK1 SRPK2 SUPT5H TCF4 TERT UBE3A USP4 WBP4 YY1
Entrez ID		7375	5478
HPRD ID		04598	00457
Ensembl ID		ENSG00000114316	ENSG00000196262
Uniprot IDs		Q08AK7 Q13107	P62937 V9HWF5
PDB IDs		2Y6E 5CTR	1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E 1M9F 1M9X 1M9Y 1MF8 1MIK 1NMK 1OCA 1RMH 1VBS 1VBT 1W8L 1W8M 1W8V 1YND 1ZKF 2ALF 2CPL 2CYH 2MS4 2MZU 2N0T 2RMA 2RMB 2X25 2X2A 2X2C 2X2D 2XGY 3CYH 3CYS 3K0M 3K0N 3K0O 3K0P 3K0Q 3K0R 3ODI 3ODL 3RDD 4CYH 4IPZ 4N1M 4N1N 4N1O 4N1P 4N1Q 4N1R 4N1S 4YUG 4YUH 4YUI 4YUJ 4YUK 4YUL 4YUM 4YUN 4YUO 4YUP 5CYH 5F66 5FJB 5KUL 5KUN 5KUO 5KUQ 5KUR 5KUS 5KUU 5KUV 5KUW 5KUZ 5KV0 5KV1 5KV2 5KV3 5KV4 5KV5 5KV6 5KV7 5LUD 5NOQ 5NOR 5NOS 5NOT 5NOU 5NOV 5NOW 5NOX 5NOY 5NOZ 5T9U 5T9W 5T9Z 5TA2 5TA4 5WC7 6BTA 6GJI 6GJJ 6GJL 6GJM 6GJN 6GJP 6GJR 6GJY 6GS6 6I42 6U5C 6U5D 6U5E 6U5G 6X3R 6X3Y 6X4M 6X4N 6X4O 6X4P 6X4Q 6Y9V 6Y9W 6Y9X 6Y9Y 6Y9Z 6ZDJ 7ABT 7N9X 7PCJ 7QBW 7TA8 7UPN 7UXJ 7UXM 7UXN 8G9P 8G9Q 8HZ8 8TBF 8TBG 8TBH 8TBI 8TBJ 8TBK 8TBL 8TBM 8TBN 9AX6 9BFW 9BFY 9BFZ 9BG1 9BHO 9BHP 9BHQ 9BI1 9BI2 9GHY
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Intracellular Signal Transduction Nucleoplasm Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Intracellular Signaling Cassette Macromolecule Metabolic Process Extracellular Exosome PCNA-p21 Complex Regulation Of Kinase Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Nucleus Identical Protein Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity TORC1 Signaling Regulation Of Cell Cycle Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Protein-containing Complex Cytoplasm Cytosol Response To External Biotic Stimulus Negative Regulation Of Cell Cycle Signal Transduction Positive Regulation Of Potassium Ion Import Across Plasma Membrane Sulfate Binding Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle TOR Signaling Cell Cycle G1/S Phase Transition Positive Regulation Of Sodium Ion Transport NF-kappaB Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Potassium Ion Import Cellular Response To Chemical Stress Protein Modification Process Negative Regulation Of Cell Cycle Process Epithelial Cell Differentiation DNA-binding Transcription Factor Binding Positive Regulation Of Interleukin-2 Production Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Developmental Process Nucleus Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Endosome Lumen Regulation Of MiRNA Transcription Regulation Of Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Activation Of Janus Kinase Activity Intracellular Signal Transduction Regulation Of Cell Differentiation Immune System Process Regulation Of RNA Metabolic Process Regulation Of Cytokine Production Regulation Of Primary Metabolic Process Regulation Of Neuron Apoptotic Process Chromatin Organization Response To Stress Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Signaling Receptor Activator Activity Embryo Implantation Nucleic Acid Metabolic Process Immunoglobulin V(D)J Recombination Chromatin Remodeling Neutrophil Chemotaxis Hormone-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Prostate Gland Growth Cellular Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Development Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Mammary Gland Epithelium Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Viral Process
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