USP4

Description		ubiquitin specific peptidase 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Cytoplasmic Translation Proteolysis Cellular Response To Starvation Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Protein Localization To Cell Surface TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)
Novel Interacting Genes		49 novel interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BDKRB2 BRAP CDKN1A CIAO2B DLC1 HDAC2 IGKV2D-29 IRF4 LAMA5 LGALS1 MAP3K7 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28
Interacting Genes		49 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BDKRB2 BRAP CDKN1A CIAO2B DLC1 HDAC2 IGKV2D-29 IRF4 LAMA5 LGALS1 MAP3K7 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28
Entrez ID		7375
HPRD ID		04598
Ensembl ID		ENSG00000114316
Uniprot IDs		Q08AK7 Q13107
PDB IDs		2Y6E 5CTR
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Intracellular Signal Transduction Nucleoplasm Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Intracellular Signaling Cassette Macromolecule Metabolic Process Extracellular Exosome PCNA-p21 Complex Regulation Of Kinase Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Nucleus Identical Protein Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity TORC1 Signaling Regulation Of Cell Cycle Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Protein-containing Complex Cytoplasm Cytosol Response To External Biotic Stimulus Negative Regulation Of Cell Cycle Signal Transduction Positive Regulation Of Potassium Ion Import Across Plasma Membrane Sulfate Binding Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle TOR Signaling Cell Cycle G1/S Phase Transition Positive Regulation Of Sodium Ion Transport NF-kappaB Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Potassium Ion Import Cellular Response To Chemical Stress Protein Modification Process Negative Regulation Of Cell Cycle Process Epithelial Cell Differentiation DNA-binding Transcription Factor Binding Positive Regulation Of Interleukin-2 Production Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition
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