RRAGD and ITGB8

		RRAGD	ITGB8
Description		Ras related GTP binding D	integrin subunit beta 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Centrosome Cytosol Membrane Gtr1-Gtr2 GTPase Complex	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alphav-beta8 Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Heterodimerization Activity GTPase Binding Molecular Adaptor Activity	Integrin Binding Metal Ion Binding Extracellular Matrix Protein Binding
	Biological Process	Intracellular Protein Localization Cellular Response To Starvation Negative Regulation Of Autophagy Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Response To Amino Acid Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Vasculogenesis Ganglioside Metabolic Process Immune Response Cell Adhesion Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Cell Differentiation Cell Adhesion Mediated By Integrin Positive Regulation Of Angiogenesis Cartilage Development Hard Palate Development Placenta Blood Vessel Development Langerhans Cell Differentiation Cell-cell Adhesion
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs
Drugs
Diseases
GWAS		Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate ( 29403010)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 34103634 31959851 31619474 31361310 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Eosinophil count ( 29403010 32888494) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Prostate cancer ( 29892016) Type 1 diabetes ( 34012112) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: CHST15 ITGB8 NOL8 RRAGB	14 interacting genes: CHN2 DYRK1A HOXA1 ITGAV PPP1CA PPP1R9B PSPH RAPGEF5 RRAGD SH2D3A SP4 TGFB1 TOMM7 VTN
Entrez ID		58528	3696
HPRD ID		12199	05001
Ensembl ID		ENSG00000025039	ENSG00000105855
Uniprot IDs		Q9NQL2	P26012 Q9BUG9
PDB IDs		2Q3F	6DJP 6OM1 6OM2 6UJA 6UJB 6UJC 7Y1T 8TCF 8VS6 8VSD 9IND
Enriched GO Terms of Interacting Partners?		Integrin Alphav-beta8 Complex Guanyl Ribonucleotide Binding N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase Activity Langerhans Cell Differentiation Gtr1-Gtr2 GTPase Complex Extracellular Matrix Protein Binding	Histone H3T45 Kinase Activity Semicircular Canal Formation Entry Into Host Cell By A Symbiont-containing Vacuole Endodermal Cell Differentiation Extracellular Matrix Binding Opsonin Binding Cell Adhesion Mediated By Integrin Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Complex Response To Ketone L-phosphoserine Phosphatase Activity Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Liver Regeneration Regulation Of Exit From Mitosis Response To Immobilization Stress Cellular Response To Acetaldehyde Symbiont-containing Vacuole Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Animal Organ Regeneration Inner Ear Development Regulation Of Signal Transduction Double-strand Break Repair Via Nonhomologous End Joining
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