ITGB8 and TOMM7

		ITGB8	TOMM7
Description		integrin subunit beta 8	translocase of outer mitochondrial membrane 7
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alphav-beta8 Complex Extracellular Exosome	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane TOM Complex
	Molecular Function	Integrin Binding Metal Ion Binding Extracellular Matrix Protein Binding	Protein Binding Protein Transmembrane Transporter Activity
	Biological Process	Vasculogenesis Ganglioside Metabolic Process Immune Response Cell Adhesion Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Cell Differentiation Cell Adhesion Mediated By Integrin Positive Regulation Of Angiogenesis Cartilage Development Hard Palate Development Placenta Blood Vessel Development Langerhans Cell Differentiation Cell-cell Adhesion	Protein Transport Protein Import Into Mitochondrial Matrix Regulation Of Protein Stability Protein Insertion Into Mitochondrial Outer Membrane Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Type 2 Mitophagy
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy
Drugs
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 34103634 31959851 31619474 31361310 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Eosinophil count ( 29403010 32888494) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Prostate cancer ( 29892016) Type 1 diabetes ( 34012112) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 30929738 31959851 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: CHN2 DYRK1A HOXA1 ITGAV PPP1CA PPP1R9B PSPH RAPGEF5 RRAGD SH2D3A SP4 TGFB1 TOMM7 VTN	5 interacting genes: DHFR ITGB8 PEX5 TOMM22 TOMM40
Entrez ID		3696	54543
HPRD ID		05001	16266
Ensembl ID		ENSG00000105855	ENSG00000196683
Uniprot IDs		P26012 Q9BUG9	Q75MR5 Q9P0U1
PDB IDs		6DJP 6OM1 6OM2 6UJA 6UJB 6UJC 7Y1T 8TCF 8VS6 8VSD 9IND	7CK6 7CP9 7VBY 7VC4 7VD2 7VDD 8XVA 9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Histone H3T45 Kinase Activity Semicircular Canal Formation Entry Into Host Cell By A Symbiont-containing Vacuole Endodermal Cell Differentiation Extracellular Matrix Binding Opsonin Binding Cell Adhesion Mediated By Integrin Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Complex Response To Ketone L-phosphoserine Phosphatase Activity Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Liver Regeneration Regulation Of Exit From Mitosis Response To Immobilization Stress Cellular Response To Acetaldehyde Symbiont-containing Vacuole Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Animal Organ Regeneration Inner Ear Development Regulation Of Signal Transduction Double-strand Break Repair Via Nonhomologous End Joining	Protein Transmembrane Transport Mitochondrial Membrane Organization Mitochondrial Outer Membrane Translocase Complex TOM Complex Protein Insertion Into Mitochondrial Outer Membrane Establishment Of Protein Localization To Membrane Protein Targeting Protein Import Into Mitochondrial Matrix Protein Transmembrane Transporter Activity Protein Targeting To Mitochondrion Mitochondrion Organization Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Protein Localization To Mitochondrion Establishment Of Protein Localization To Organelle Protein Insertion Into Membrane Establishment Of Protein Localization To Mitochondrion Response To Methotrexate Localization Within Membrane Mitochondrion Dihydrofolate Reductase Activity Integrin Alphav-beta8 Complex Membrane Organization Protein Localization To Organelle Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Dihydrofolate Metabolic Process Peroxisome Targeting Sequence Binding Langerhans Cell Differentiation Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Extracellular Matrix Protein Binding Mitochondrial Outer Membrane Mitochondrion Targeting Sequence Binding Regulation Of Removal Of Superoxide Radicals Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Porin Activity Tetrahydrofolate Biosynthetic Process Tetrahydrobiopterin Biosynthetic Process Protein Transport Folic Acid-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Hard Palate Development Transmembrane Transport Folic Acid Binding Regulation Of Response To Reactive Oxygen Species Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?