POLD4 and WRNIP1

Number of citations of the paper that reports this interaction (PubMedID 15670210)
0

Data Source:
HPRD (in vitro)

		POLD4	WRNIP1
Description		DNA polymerase delta 4, accessory subunit	WRN helicase interacting protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Delta DNA Polymerase Complex	Chromosome, Telomeric Region Nucleus Cytoplasm Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding	Nucleotide Binding DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	DNA Synthesis Involved In DNA Repair Positive Regulation Of Endothelial Cell Proliferation DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response	DNA Synthesis Involved In DNA Repair Immune System Process DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response Regulation Of DNA-templated DNA Replication Initiation Innate Immune Response
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Plateletcrit ( 32888494)
Interacting Genes		9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1	16 interacting genes: ABL1 BBS2 CEBPA ERBB3 FXR1 PIK3R3 PIN1 POLD1 POLD2 POLD4 RIPK1 RNF26 TOLLIP TRIM14 UBC WRN
Entrez ID		57804	56897
HPRD ID		17873	10494
Ensembl ID		ENSG00000175482	ENSG00000124535
Uniprot IDs		Q6NSD7 Q9HCU8	Q96S55
PDB IDs		6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB	3VHS 3VHT
Enriched GO Terms of Interacting Partners?		DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process DNA Replication Translesion Synthesis Postreplication Repair DNA Repair DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Metabolic Process DNA Strand Elongation DNA Damage Response Delta DNA Polymerase Complex Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Biosynthetic Process Base-excision Repair, Gap-filling Cellular Response To Stress DNA-directed DNA Polymerase Activity Nucleic Acid Metabolic Process DNA Replication Proofreading Macromolecule Biosynthetic Process Chromosome, Telomeric Region Leading Strand Elongation Zeta DNA Polymerase Complex Nucleobase-containing Compound Metabolic Process Response To Stress Error-prone Translesion Synthesis DNA Polymerase Activity Response To Radiation Response To UV Chromatin Binding Mismatch Repair 4 Iron, 4 Sulfur Cluster Binding Macromolecule Metabolic Process PCNA Complex Damaged DNA Binding Replisome Response To Light Stimulus Iron-sulfur Cluster Binding Nucleoplasm Cellular Response To UV PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleotidyltransferase Activity Cellular Response To Light Stimulus Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Regulation Of DNA Replication DNA Synthesis Involved In UV-damage Excision Repair Regulation Of DNA Metabolic Process	Delta DNA Polymerase Complex DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Response To Stress DNA-templated DNA Replication DNA Replication Macromolecule Metabolic Process Bubble DNA Binding Cellular Response To Stress Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Intracellular Signaling Cassette DNA Repair 3'-5' Exonuclease Activity Positive Regulation Of Macromolecule Metabolic Process Four-way Junction DNA Binding DNA Conformation Change Ubiquitin Protein Ligase Binding DNA-directed DNA Polymerase Activity Translesion Synthesis Positive Regulation Of Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Mismatch Repair DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Postreplication Repair Positive Regulation Of Gene Expression DNA Damage Response Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Long-term Synaptic Potentiation Phosphotyrosine Residue Binding Protein Localization To Cytoplasmic Microtubule Plus-end Positive Regulation Of Developmental Process Nucleobase-containing Compound Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cis-trans Isomerase Activity Exonuclease Activity Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Inflammatory Response Canonical NF-kappaB Signal Transduction Positive Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?