WRNIP1

Description		WRN helicase interacting protein 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Cytoplasm Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	DNA Synthesis Involved In DNA Repair Immune System Process DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response Regulation Of DNA-templated DNA Replication Initiation Innate Immune Response
Pathways
Drugs
Diseases
GWAS		Plateletcrit ( 32888494)
Novel Interacting Genes		16 novel interacting genes: ABL1 BBS2 CEBPA ERBB3 FXR1 PIK3R3 PIN1 POLD1 POLD2 POLD4 RIPK1 RNF26 TOLLIP TRIM14 UBC WRN
Interacting Genes		16 interacting genes: ABL1 BBS2 CEBPA ERBB3 FXR1 PIK3R3 PIN1 POLD1 POLD2 POLD4 RIPK1 RNF26 TOLLIP TRIM14 UBC WRN
Entrez ID		56897
HPRD ID		10494
Ensembl ID		ENSG00000124535
Uniprot IDs		Q96S55
PDB IDs		3VHS 3VHT
Enriched GO Terms of Interacting Partners?		Delta DNA Polymerase Complex DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Response To Stress DNA-templated DNA Replication DNA Replication Macromolecule Metabolic Process Bubble DNA Binding Cellular Response To Stress Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Intracellular Signaling Cassette DNA Repair 3'-5' Exonuclease Activity Positive Regulation Of Macromolecule Metabolic Process Four-way Junction DNA Binding DNA Conformation Change Ubiquitin Protein Ligase Binding DNA-directed DNA Polymerase Activity Translesion Synthesis Positive Regulation Of Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Mismatch Repair DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Postreplication Repair Positive Regulation Of Gene Expression DNA Damage Response Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Long-term Synaptic Potentiation Phosphotyrosine Residue Binding Protein Localization To Cytoplasmic Microtubule Plus-end Positive Regulation Of Developmental Process Nucleobase-containing Compound Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cis-trans Isomerase Activity Exonuclease Activity Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Inflammatory Response Canonical NF-kappaB Signal Transduction Positive Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process
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