POLD4

Description		DNA polymerase delta 4, accessory subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Delta DNA Polymerase Complex
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair Positive Regulation Of Endothelial Cell Proliferation DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Novel Interacting Genes		9 novel interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1
Interacting Genes		9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1
Entrez ID		57804
HPRD ID		17873
Ensembl ID		ENSG00000175482
Uniprot IDs		Q6NSD7 Q9HCU8
PDB IDs		6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB
Enriched GO Terms of Interacting Partners?		DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process DNA Replication Translesion Synthesis Postreplication Repair DNA Repair DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Metabolic Process DNA Strand Elongation DNA Damage Response Delta DNA Polymerase Complex Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Biosynthetic Process Base-excision Repair, Gap-filling Cellular Response To Stress DNA-directed DNA Polymerase Activity Nucleic Acid Metabolic Process DNA Replication Proofreading Macromolecule Biosynthetic Process Chromosome, Telomeric Region Leading Strand Elongation Zeta DNA Polymerase Complex Nucleobase-containing Compound Metabolic Process Response To Stress Error-prone Translesion Synthesis DNA Polymerase Activity Response To Radiation Response To UV Chromatin Binding Mismatch Repair 4 Iron, 4 Sulfur Cluster Binding Macromolecule Metabolic Process PCNA Complex Damaged DNA Binding Replisome Response To Light Stimulus Iron-sulfur Cluster Binding Nucleoplasm Cellular Response To UV PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleotidyltransferase Activity Cellular Response To Light Stimulus Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Regulation Of DNA Replication DNA Synthesis Involved In UV-damage Excision Repair Regulation Of DNA Metabolic Process
Tagcloud ?