EP400 and BRD8

Number of citations of the paper that reports this interaction (PubMedID 35636729)
78

Data Source:
BioGRID (pull down)

		EP400	BRD8
Description		E1A binding protein p400	bromodomain containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Swr1 Complex Nucleus Nucleoplasm Nuclear Speck NuA4 Histone Acetyltransferase Complex	Nucleosome Swr1 Complex Nucleus Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Protein Antigen Binding	Transcription Coactivator Activity Protein Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	DNA Repair Chromatin Organization Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Chromatin Organization Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF) DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones	HATs acetylate histones
Drugs
Diseases
GWAS		Body mass index ( 26426971) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Menarche (age at onset) ( 25231870)
Interacting Genes		15 interacting genes: ALAS1 ATM BRD8 CEBPA KAT5 MNS1 MYC NTAQ1 POLR1C RAD51 SUMO2 TBC1D4 TRAF2 TRRAP ZGPAT	15 interacting genes: AGTR1 CD276 EP400 EP400P1 FSD2 IL3 MCRS1 MIS18A MRGBP PIN1 PPARG RXRA THRB TRRAP WEE1
Entrez ID		57634	10902
HPRD ID		09378	04166
Ensembl ID		ENSG00000183495	ENSG00000112983
Uniprot IDs		Q96L91	B4DEG9 B4DMS9 B4DN43 Q9H0E9
PDB IDs		8QR1 8QRI 8XVG 8XVT 8XVV 9C47 9C57 9C62 9C6N
Enriched GO Terms of Interacting Partners?		Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Recombination Swr1 Complex Nucleoplasm Positive Regulation Of DNA Recombination Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair NuA4 Histone Acetyltransferase Complex Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of DNA Repair Regulation Of Cell Cycle Cellular Response To Oxygen-containing Compound Response To Xenobiotic Stimulus Site Of Double-strand Break Nucleolus Positive Regulation Of Chromosome Organization Transcription By RNA Polymerase I Nucleosome Protein-containing Complex Binding Positive Regulation Of RNA Biosynthetic Process DNA Double-strand Break Processing Response To X-ray Cellular Response To Gamma Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Recombinational Repair Reciprocal Meiotic Recombination Response To Ionizing Radiation Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA-templated Transcription Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break DNA Repair-dependent Chromatin Remodeling Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Radiation DNA-binding Transcription Factor Binding Homologous Recombination Chromatin Organization Meiosis I	Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process NuA4 Histone Acetyltransferase Complex DNA Binding Domain Binding Positive Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipoprotein Transport MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Receptor Activity Positive Regulation Of Metabolic Process LBD Domain Binding MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Swr1 Complex Regulation Of DNA Repair Positive Regulation Of DNA Recombination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Monocyte Differentiation Nucleosome Regulation Of Cell Cycle RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Lipid Metabolic Process Regulation Of Lipid Transport Regulation Of DNA Recombination Negative Regulation Of SMAD Protein Signal Transduction Hormone-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Double-strand Break Repair Peptide Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of Macrophage Derived Foam Cell Differentiation Nucleoplasm Regulation Of Metabolic Process Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Chromatin Organization Transcription Coregulator Binding Regulation Of Cholesterol Efflux
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