BRD8 and EP400

Number of citations of the paper that reports this interaction (PubMedID 35636729)
78

Data Source:
BioGRID (pull down)

		BRD8	EP400
Description		bromodomain containing 8	E1A binding protein p400
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Swr1 Complex Nucleus Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex	Nucleosome Swr1 Complex Nucleus Nucleoplasm Nuclear Speck NuA4 Histone Acetyltransferase Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Nuclear Thyroid Hormone Receptor Binding	Nucleotide Binding DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Protein Antigen Binding
	Biological Process	Chromatin Organization Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	DNA Repair Chromatin Organization Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		HATs acetylate histones	Formation of Senescence-Associated Heterochromatin Foci (SAHF) DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Menarche (age at onset) ( 25231870)	Body mass index ( 26426971) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		15 interacting genes: AGTR1 CD276 EP400 EP400P1 FSD2 IL3 MCRS1 MIS18A MRGBP PIN1 PPARG RXRA THRB TRRAP WEE1	15 interacting genes: ALAS1 ATM BRD8 CEBPA KAT5 MNS1 MYC NTAQ1 POLR1C RAD51 SUMO2 TBC1D4 TRAF2 TRRAP ZGPAT
Entrez ID		10902	57634
HPRD ID		04166	09378
Ensembl ID		ENSG00000112983	ENSG00000183495
Uniprot IDs		B4DEG9 B4DMS9 B4DN43 Q9H0E9	Q96L91
PDB IDs			8QR1 8QRI 8XVG 8XVT 8XVV 9C47 9C57 9C62 9C6N
Enriched GO Terms of Interacting Partners?		Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process NuA4 Histone Acetyltransferase Complex DNA Binding Domain Binding Positive Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipoprotein Transport MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Receptor Activity Positive Regulation Of Metabolic Process LBD Domain Binding MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Swr1 Complex Regulation Of DNA Repair Positive Regulation Of DNA Recombination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Monocyte Differentiation Nucleosome Regulation Of Cell Cycle RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Lipid Metabolic Process Regulation Of Lipid Transport Regulation Of DNA Recombination Negative Regulation Of SMAD Protein Signal Transduction Hormone-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Double-strand Break Repair Peptide Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of Macrophage Derived Foam Cell Differentiation Nucleoplasm Regulation Of Metabolic Process Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Chromatin Organization Transcription Coregulator Binding Regulation Of Cholesterol Efflux	Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Recombination Swr1 Complex Nucleoplasm Positive Regulation Of DNA Recombination Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair NuA4 Histone Acetyltransferase Complex Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of DNA Repair Regulation Of Cell Cycle Cellular Response To Oxygen-containing Compound Response To Xenobiotic Stimulus Site Of Double-strand Break Nucleolus Positive Regulation Of Chromosome Organization Transcription By RNA Polymerase I Nucleosome Protein-containing Complex Binding Positive Regulation Of RNA Biosynthetic Process DNA Double-strand Break Processing Response To X-ray Cellular Response To Gamma Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Recombinational Repair Reciprocal Meiotic Recombination Response To Ionizing Radiation Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA-templated Transcription Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break DNA Repair-dependent Chromatin Remodeling Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Radiation DNA-binding Transcription Factor Binding Homologous Recombination Chromatin Organization Meiosis I
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