ISLR2 and EMP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ISLR2	EMP1
Description		immunoglobulin superfamily containing leucine rich repeat 2	epithelial membrane protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Nervous System Development Positive Regulation Of Axon Extension	Apoptotic Process Epidermis Development Bleb Assembly
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Coronary artery calcification ( 23870195) Degraded stimulus continuous performance test score ( 31596458) Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136) Heel bone mineral density ( 28869591 30598549) Household income (MTAG) ( 31844048) Refractive error ( 32231278) Serum albumin levels ( 29403010)
Interacting Genes		6 interacting genes: EMP1 LAPTM4B MRAP2 NKG7 STRIT1 UPK1B	63 interacting genes: ANK1 ANKS6 APOL2 AQP6 ARL13B ARL6IP1 ASGR2 ATP6V0B ATP6V0E1 BTN2A2 C1QBP CATSPERH CCR5 CD37 CD3G CD40 CD53 CD79A CEP70 CLDN9 CORIN CXCR2 EBP EDA EHHADH ERGIC3 FFAR2 GIMAP5 GPR42 GPRC5D HTR2C ISLR2 JPH1 KLRC1 LAPTM4B LEPROTL1 LHFPL5 LPAR6 LRRC3B LSMEM2 MAL MALL MS4A7 OPRM1 PLEKHB2 PMP22 RABAC1 RPRM SERTM1 SMIM3 SPACA1 STOM SYNE4 TBXA2R TEX264 TLCD4 TMEM114 TMEM160 TMEM218 TMEM239 TMEM31 TMEM9 TSPO2
Entrez ID		57611	2012
HPRD ID		13865	11892
Ensembl ID		ENSG00000167178	ENSG00000134531
Uniprot IDs		Q6UXK2	P54849
PDB IDs
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cytolytic Granule Membrane Apical Plasma Membrane Urothelial Plaque Regulation Of Lysosomal Membrane Permeability Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Corticotropin Hormone Receptor Binding Type 1 Melanocortin Receptor Binding Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Lysosomal Protein Catabolic Process Multivesicular Body, Internal Vesicle Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Natural Killer Cell Degranulation Immune Response To Tumor Cell Signaling Receptor Regulator Activity Ceramide Binding Bleb Assembly Membrane Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Phosphatidylinositol Bisphosphate Binding Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Lysosome Organization Lysosomal Membrane Organization Regulation Of Skeletal Muscle Contraction Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Membrane Plasma Membrane Protein Binding G Protein-coupled Receptor Activity External Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Multivesicular Body Membrane
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