ISLR2

Description		immunoglobulin superfamily containing leucine rich repeat 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding
	Biological Process	Nervous System Development Positive Regulation Of Axon Extension
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)
Novel Interacting Genes		6 novel interacting genes: EMP1 LAPTM4B MRAP2 NKG7 STRIT1 UPK1B
Interacting Genes		6 interacting genes: EMP1 LAPTM4B MRAP2 NKG7 STRIT1 UPK1B
Entrez ID		57611
HPRD ID		13865
Ensembl ID		ENSG00000167178
Uniprot IDs		Q6UXK2
PDB IDs
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cytolytic Granule Membrane Apical Plasma Membrane Urothelial Plaque Regulation Of Lysosomal Membrane Permeability Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Corticotropin Hormone Receptor Binding Type 1 Melanocortin Receptor Binding Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Lysosomal Protein Catabolic Process Multivesicular Body, Internal Vesicle Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Natural Killer Cell Degranulation Immune Response To Tumor Cell Signaling Receptor Regulator Activity Ceramide Binding Bleb Assembly Membrane Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Phosphatidylinositol Bisphosphate Binding Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Lysosome Organization Lysosomal Membrane Organization Regulation Of Skeletal Muscle Contraction Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
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