MAP2K7 and CFLAR

Number of citations of the paper that reports this interaction (PubMedID 17110930)
39

Data Source:
HPRD (in vivo)

		MAP2K7	CFLAR
Description		mitogen-activated protein kinase kinase 7	CASP8 and FADD like apoptosis regulator
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Cysteine-type Peptidase Activity Protein-containing Complex Binding
	Biological Process	Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Response To Heat Response To UV Response To Wounding Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Telomere Maintenance Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Senescence Regulation Of Motor Neuron Apoptotic Process	Response To Hypoxia Proteolysis Apoptotic Process Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Macrophage Differentiation Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Skeletal Muscle Tissue Regeneration Positive Regulation Of Neuron Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins	TRAIL signaling
Drugs		Pimasertib
Diseases
GWAS		Appendicular lean mass ( 33097823) Fasting insulin ( 34059833) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 23823483) Type 2 diabetes ( 30297969 32499647)	Appendicular lean mass ( 33097823) Rheumatoid arthritis ( 24390342 30423114) Triptolide cytotoxicity ( 26121980)
Interacting Genes		34 interacting genes: ARR3 ATF4 CEBPA CFLAR CNKSR1 DUSP19 DUSP22 GADD45B ICAM1 JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2	49 interacting genes: ATF2 BCL2L1 CAB39 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CD28 CRYGA CUL1 DAXX DEDD DEDD2 ECE1 EEF1B2 FADD FGF13 FZD5 GAPDHS GJA1 IKBKB KCNIP3 MAP2K4 MAP2K7 MEX3B MYL1 NDUFS1 NEURL3 NFKB1 PROC PSEN2 QPCT RAF1 RBX1 RIPK1 RIPK2 RLIM RNF8 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 TRIM31 USP8
Entrez ID		5609	8837
HPRD ID		04309	04671
Ensembl ID		ENSG00000076984	ENSG00000003402
Uniprot IDs		B4DV95 O14733	A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61
PDB IDs		2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR 6YFZ 6YG0 6YG1 6YG2 6YG3 6YG4 6YG5 6YG6 6YG7 6YZ4 7CBX 7OVI 7OVJ 7OVK 7OVL 7OVM 7OVN	2N5R 3H11 3H13 6M6O 7DEE 7LXC 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN
Enriched GO Terms of Interacting Partners?		MAPK Cascade MAP Kinase Kinase Kinase Activity Intracellular Signaling Cassette JNK Cascade Regulation Of MAPK Cascade Protein Serine Kinase Activity Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Kinase Activity Regulation Of JNK Cascade Signal Transduction Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphorylation Positive Regulation Of Signal Transduction Protein Kinase Binding Cytoplasm JUN Kinase Kinase Kinase Activity ATP Binding Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Programmed Cell Death Transferase Activity MAP-kinase Scaffold Activity Cellular Response To Stress MAP Kinase Activity Positive Regulation Of Programmed Cell Death Fc-epsilon Receptor Signaling Pathway Cellular Response To Oxidative Stress P38MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of P38MAPK Cascade Nucleotide Binding Positive Regulation Of Apoptotic Process Regulation Of Immune System Process Cellular Response To Chemical Stress Mitogen-activated Protein Kinase Kinase Binding Protein Modification Process Integrated Stress Response Signaling	Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway Signal Transduction Protein Metabolic Process JNK Cascade Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Ripoptosome Intracellular Signaling Cassette Positive Regulation Of Neuron Apoptotic Process Proteolysis Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Execution Phase Of Apoptosis Response To Stress Cytosol Protein Modification Process Post-translational Protein Modification Response To External Biotic Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Staurosporine Death Effector Domain Binding Protein Polyubiquitination Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death Receptor Binding T Cell Activation Regulation Of Intracellular Signal Transduction Protein Maturation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cytokine Production
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