KMT2E and TRAPPC14

		KMT2E	TRAPPC14
Description		lysine methyltransferase 2E (inactive)	trafficking protein particle complex subunit 14
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Plasma Membrane Membrane Nuclear Body Nuclear Speck Protein-containing Complex Set3 Complex Rpd3L-Expanded Complex	Cytoplasm Spindle Cytoskeleton Plasma Membrane Midbody Vesicle Centriolar Satellite Mitotic Spindle TRAPPII Protein Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3 Methyltransferase Activity	Protein Binding Alpha-tubulin Binding
	Biological Process	Neutrophil Mediated Immunity Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Gene Expression Erythrocyte Differentiation Epigenetic Regulation Of Gene Expression Neutrophil Activation Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cell Projection Organization Regulation Of Cell Population Proliferation Cilium Assembly
Pathways
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		14 interacting genes: ALKBH4 ASH2L ATP13A1 CDCA8 CDK1 CRK CYP2C18 FIS1 IFT22 LAMTOR5 MAPRE2 NFE4 TRAPPC14 ZCWPW1	10 interacting genes: AGXT CYSRT1 KMT2E KRTAP6-1 MEPCE NBPF19 NOTCH2NLA TGM1 TMEM50A VWC2
Entrez ID		55904	55262
HPRD ID		10528	07716
Ensembl ID		ENSG00000005483	ENSG00000146826
Uniprot IDs		Q8IZD2	B3KNS5 Q8WVR3
PDB IDs		2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Regulation Of Metaphase Plate Congression Regulation Of Attachment Of Spindle Microtubules To Kinetochore Organelle Assembly Spindle Midzone Positive Regulation Of Chromosome Segregation Protein-containing Complex Pronuclear Fusion Spindle Cytoskeleton Organization DNA N6-methyladenine Demethylase Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Positive Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Mitotic DNA-templated DNA Replication Cellular Component Assembly Cyclin B1-CDK1 Complex Cilium Organization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Helper T Cell Diapedesis Positive Regulation Of Intracellular Signal Transduction Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Small GTPase Mediated Signal Transduction Linoleic Acid Epoxygenase Activity Epigenetic Regulation Of Gene Expression Positive Regulation Of ARF Protein Signal Transduction Cleavage Furrow Ingression Intracellular Protein Localization Response To Activity Regulation Of Organelle Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Chromosome Organization Cyclin-dependent Protein Kinase Activity Cerebellar Neuron Development Response To Flavonoid P-type Transmembrane Transporter Activity Spindle Assembly Regulation Of Schwann Cell Differentiation Response To Hydrogen Peroxide Microtubule-based Process Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Protein Localization To Nucleus Response To Toxic Substance	Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-serine-pyruvate Transaminase Activity Oxalic Acid Secretion Cornified Envelope Positive Regulation Of Cell Cycle Keratinization Cell Envelope Organization Set3 Complex Positive Regulation Of Cell Cycle G1/S Phase Transition Rpd3L-Expanded Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle RNA 5'-gamma-phosphate Methyltransferase Activity Glycine Biosynthetic Process Notch Signaling Pathway Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP SnRNA Modification Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle O-methyltransferase Activity Interstitial Matrix Oxalate Transport Glyoxylate Metabolic Process Extrinsic Component Of Postsynaptic Membrane Regulation Of Cell Cycle G1/S Phase Transition 7SK SnRNA Binding Positive Regulation Of Protein Localization To Cajal Body Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process SnRNA Binding
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